Associated Genetic Biomarkers

Overview

NCI Definition: The most frequent type of acute lymphoblastic leukemia. Approximately 75% of cases occur in children under six years of age. This is a good prognosis leukemia. In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%. Approximately 80% of children appear to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, 2001) [1]

B-cell acute lymphoblastic leukemias most frequently harbor alterations in NRAS, KRAS, CDKN2A, TP53, and CDKN2B [2].

Most Commonly Altered Genes in B-Cell Acute Lymphoblastic Leukemia

NRAS Mutation, KRAS Mutation, NRAS Exon 2 Mutation, NRAS Exon 2 Missense, and KRAS Exon 2 Mutation are the most common alterations in B-cell acute lymphoblastic leukemia [2].

Top Alterations in B-Cell Acute Lymphoblastic Leukemia

Significant Genes in B-Cell Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

BCR +

CRLF2 +

CSF1R +

DEK +

ELL +

EPOR +

FGFR1 +

FGFR2 +

FLT3 +

HLF +

IGH +

IGK +

IGL +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NUP214 +

PBX1 +

PDGFRA +

PDGFRB +

RPN1 +

RUNX1 +

SH2B3 +

TCF3 +

TP53 +

TRA +

TRB +

TRD +

TRG +

Disease Details

Synonyms
B-ALL, B-cell precursor acute lymphoblastic leukemia, Precursor B-Lymphoblastic Leukemia, B-Cell Precursor Type Acute Leukemia
Parent(s)
B-Cell Lymphoblastic Leukemia/Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.