Overview

NCI Definition: A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. [1]

Diffuse astrocytomas most frequently harbor alterations in TP53, IDH1, and ATRX [2].

Most Commonly Altered Genes in Diffuse Astrocytoma

TP53 c.217-c.1178 Missense, TP53 Mutation (somatic), TP53 Mutation (germline), TP53 Mutation, and TP53 Missense (germline) are the most common alterations in diffuse astrocytoma [2].

Top Alterations in Diffuse Astrocytoma

Significant Genes in Diffuse Astrocytoma

EGFR +

IDH1 +

IDH2 +

TERT +

Disease Details

Synonyms
WHO Grade II Astrocytoma, Grade II Astrocytic Neoplasm, ASTROCYTOMA, DIFFUSE, MALIGNANT, Low-grade astrocytoma, NOS, Grade II Astrocytic Tumor, Grade II Astrocytoma, Astrocytoma, Diffuse
Parent(s)
WHO Grade II Glioma
Children
Fibrillary Astrocytoma, Gemistocytic Astrocytoma, Protoplasmic Astrocytoma, and Childhood Diffuse Astrocytoma
OncoTree Name
Diffuse Astrocytoma
OncoTree Code
DASTR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.