Overview

NCI Definition: A glioma that has diffusely infiltrated the surrounding central nervous system tissues. [1]

Significant Genes in Diffuse Glioma

APC +

ARAF +

BRAF +

CDK6 +

CRKL +

CTDNEP1 +

CTNNB1 +

DDX3X +

FGFR1 +

FGFR2 +

FGFR3 +

GLI2 +

H3F3A +

HRAS +

IDH1 +

IDH2 +

KDM6A +

KMT2C +

KMT2D +

KRAS +

LRP1B +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM4 +

MYB +

MYBL1 +

MYC +

MYCL +

MYCN +

NF1 +

NF2 +

NRAS +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PTPN1 +

PVT1 +

RAF1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SOS1 +

SRC +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
Diffuse glioma WHO Grade II, Diffuse Glioma WHO Grade 2
Parent(s)
Glioma
Children
Gliomatosis Cerebri, Diffuse Astrocytoma, Diffuse Glioma, NOS, Mixed Glioma, Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Oligodendroglioma, Glioblastoma, Anaplastic Astrocytoma, and Anaplastic Oligodendroglioma
OncoTree Name
Diffuse Glioma
OncoTree Code
DIFG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.