Overview

NCI Definition: A glioma that has diffusely infiltrated the surrounding central nervous system tissues. [1]

Diffuse gliomas most frequently harbor alterations in TP53, PTEN, CDKN2A, IDH1, and EGFR [2].

Most Commonly Altered Genes in Diffuse Glioma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in diffuse glioma [2].

Top Alterations in Diffuse Glioma

Significant Genes in Diffuse Glioma

APC +

ARAF +

BRAF +

CDK6 +

CRKL +

CTDNEP1 +

CTNNB1 +

DDX3X +

FGFR1 +

FGFR2 +

FGFR3 +

GLI2 +

H3F3A +

HRAS +

IDH1 +

IDH2 +

KDM6A +

KMT2C +

KMT2D +

KRAS +

LRP1B +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM4 +

MYB +

MYBL1 +

MYC +

MYCL +

MYCN +

NF1 +

NF2 +

NRAS +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PTPN1 +

PVT1 +

RAF1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SOS1 +

SRC +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
Diffuse Glioma WHO Grade 2, Diffuse glioma WHO Grade II
Parent(s)
Glioma
Children
Diffuse Glioma, NOS, Diffuse Astrocytoma, Oligodendroglioma, Gliomatosis Cerebri, Diffuse Intrinsic Pontine Glioma, Anaplastic Oligodendroglioma, Mixed Glioma, Glioblastoma, Diffuse Midline Glioma, H3 K27M-Mutant, and Anaplastic Astrocytoma
OncoTree Name
Diffuse Glioma
OncoTree Code
DIFG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.