Overview

NCI Definition: A glioma that has diffusely infiltrated the surrounding central nervous system tissues. [1]

Diffuse gliomas most frequently harbor alterations in TP53, CDKN2A, IDH1, CDKN2B, and PTEN [2].

Most Commonly Altered Genes in Diffuse Glioma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in diffuse glioma [2].

Top Alterations in Diffuse Glioma

Significant Genes in Diffuse Glioma

APC +

CDK6 +

CTDNEP1 +

CTNNB1 +

DDX3X +

GLI2 +

H3F3A +

IDH1 +

IDH2 +

KDM6A +

KMT2C +

KMT2D +

LRP1B +

MDM4 +

MYC +

MYCL +

MYCN +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PVT1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Parent(s)
Glioma
Children
Anaplastic Astrocytoma, Oligodendroglioma, Glioblastoma, Diffuse Intrinsic Pontine Glioma, Mixed Glioma, Diffuse Glioma, NOS, Diffuse Astrocytoma, Gliomatosis Cerebri, Diffuse Midline Glioma, H3 K27M-Mutant, and Anaplastic Oligodendroglioma
OncoTree Name
Diffuse Glioma
OncoTree Code
DIFG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.