Dysembryoplastic Neuroepithelial Tumor
NCI Definition: A benign glial-neuronal neoplasm. It is usually supratentorial, located, generally, in the cortex and occurs in children and young adults with a long-standing history of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal element', characterized by columns, made up of bundles of axons, oriented perpendicularly to the cortical surface. (Adapted from WHO) 
Dysembryoplastic neuroepithelial tumors most frequently harbor alterations in FGFR1, CUX1, BRCA2, ZMYM2, and TRIM24 .
FGFR1 Mutation, FGFR1 Exon 14 Mutation, ZMYM2-FGFR1 Fusion, TRIM24-FGFR1 Fusion, and TPR-FGFR1 Fusion are the most common alterations in dysembryoplastic neuroepithelial tumor .
There is 1 clinical trial for dysembryoplastic neuroepithelial tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains dysembryoplastic neuroepithelial tumor as an inclusion criterion, 1 is no phase specified (1 open).
Standard of care is the most common intervention in dysembryoplastic neuroepithelial tumor clinical trials.
Significant Genes in Dysembryoplastic Neuroepithelial Tumor
MYCN is an inclusion eligibility criterion in 1 clinical trial for dysembryoplastic neuroepithelial tumor, of which 1 is open and 0 are closed. Of the trial that contains MYCN status and dysembryoplastic neuroepithelial tumor as inclusion criteria, 1 is no phase specified (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.