Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the fallopian tube. Most patients are postmenopausal, and postmenopausal bleeding is the most frequently seen symptom. Morphologically, the majority of fallopian tube carcinomas are serous or endometrioid adenocarcinomas. [1]

Biomarker-Directed Therapies

Significant Genes in Fallopian Tube Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

NBN +

NPM1 +

NRG1 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Cancer of the Fallopian Tube, Fallopian Tube Cancer, Cancer of Fallopian Tube, Carcinoma of Fallopian Tube, Carcinoma of the Fallopian Tube
Parent(s)
Malignant Fallopian Tube Neoplasm
Children
Fallopian Tube Adenocarcinoma, Fallopian Tube Squamous Cell Carcinoma, Hereditary Fallopian Tube Carcinoma, Fallopian Tube Gestational Choriocarcinoma, Fallopian Tube Undifferentiated Carcinoma, and Fallopian Tube Transitional Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.