Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the fallopian tube. Most patients are postmenopausal, and postmenopausal bleeding is the most frequently seen symptom. Morphologically, the majority of fallopian tube carcinomas are serous or endometrioid adenocarcinomas. [1]

Fallopian tube carcinomas most frequently harbor alterations in TP53, NOTCH3, CCNE1, BRD4, and SMARCA4 [2].

Most Commonly Altered Genes in Fallopian Tube Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 8 Mutation, and TP53fs are the most common alterations in fallopian tube carcinoma [2].

Top Alterations in Fallopian Tube Carcinoma

Biomarker-Directed Therapies

Significant Genes in Fallopian Tube Carcinoma

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CDK4 +

CDK6 +

CHEK1 +

CHEK2 +

EGFR +

ERBB2 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Carcinoma of the Fallopian Tube, Fallopian Tube Cancer, Cancer of the Fallopian Tube, Cancer of Fallopian Tube, Carcinoma of Fallopian Tube
Parent(s)
Malignant Fallopian Tube Neoplasm
Children
Fallopian Tube Transitional Cell Carcinoma, Fallopian Tube Squamous Cell Carcinoma, Fallopian Tube Gestational Choriocarcinoma, Fallopian Tube Adenocarcinoma, Fallopian Tube Undifferentiated Carcinoma, and Hereditary Fallopian Tube Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.