Associated Genetic Biomarkers

Overview

NCI Definition: A rapidly growing serous adenocarcinoma that arises from the ovary. It is characterized by the presence of high grade cytologic features and frequent mitotic figures. [1]

High grade ovarian serous adenocarcinomas most frequently harbor alterations in TP53, CCNE1, BRCA1, NF1, and BRCA2 [2].

Most Commonly Altered Genes in High Grade Ovarian Serous Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in high grade ovarian serous adenocarcinoma [2].

Top Alterations in High Grade Ovarian Serous Adenocarcinoma

Significant Genes in High Grade Ovarian Serous Adenocarcinoma

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CDK12 +

CHEK1 +

CHEK2 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

MYC +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS2 +

PPP2R1A +

PPP2R2A +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RB1 +

SLX4 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
High-Grade Ovarian Serous Adenocarcinoma
Parent(s)
Ovarian Serous Adenocarcinoma
OncoTree Name
High-Grade Serous Ovarian Cancer
OncoTree Code
HGSOC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.