Associated Genetic Biomarkers

Overview

Malignant esophagogastric neoplasms most frequently harbor alterations in TP53, CDKN2A, ERBB2, KRAS, and ARID1A [2].

Most Commonly Altered Genes in Malignant Esophagogastric Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, ERBB2 Amplification, and ARID1A Mutation are the most common alterations in malignant esophagogastric neoplasm [2].

Top Alterations in Malignant Esophagogastric Neoplasm

Significant Genes in Malignant Esophagogastric Neoplasm

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

KRAS +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Parent(s)
Malignant Digestive System Neoplasm
Children
Esophagogastric Carcinoma, Malignant Gastric Neoplasm, Malignant Esophageal Neoplasm, and Esophagogastric Smooth Muscle Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.