Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the stomach. [1]

Malignant gastric neoplasms most frequently harbor alterations in TP53, ARID1A, CDH1, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Malignant Gastric Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, ARID1A Mutation, and CDH1 Mutation are the most common alterations in malignant gastric neoplasm [2].

Top Alterations in Malignant Gastric Neoplasm

Significant Genes in Malignant Gastric Neoplasm

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

KRAS +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

SMARCB1 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Malignant Tumor of the Stomach, Malignant Tumor of Stomach, Malignant Neoplasm of Stomach, Malignant Gastric Tumor, Malignant Neoplasm of the Stomach
Parent(s)
Malignant Esophagogastric Neoplasm
Children
Gastric Liposarcoma, Gastric Leiomyosarcoma, Malignant Gastric Granular Cell Tumor, Malignant Gastric Germ Cell Tumor, Gastric Carcinoma, and Gastric Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.