Overview

NCI Definition: A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. [1]

Malignant gliomas most frequently harbor alterations in TP53, CDKN2A, PTEN, CDKN2B, and EGFR [2].

Most Commonly Altered Genes in Malignant Glioma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in malignant glioma [2].

Top Alterations in Malignant Glioma

Significant Genes in Malignant Glioma

AKT3 +

BRAF +

CCND1 +

CCND2 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2B +

CDKN2C +

EGFR +

ERBB2 +

H3F3A +

IDH1 +

IDH2 +

MTOR +

PIK3C2B +

PIK3CA +

PIK3R1 +

PTEN +

Disease Details

Synonyms
Malignant Glial Tumor, GLIOMA, MALIGNANT, Malignant Neuroglial Tumor, Malignant Neuroglial Neoplasm, Malignant Glial Neoplasm
Parent(s)
Malignant Central Nervous System Neoplasm
Children
High Grade Astrocytic Tumor, High-Grade Glioma, NOS, and WHO Grade III Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.