Overview

NCI Definition: A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. [1]

Malignant gliomas most frequently harbor alterations in TP53, CDKN2A, CDKN2B, PTEN, and EGFR [2].

Most Commonly Altered Genes in Malignant Glioma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, CDKN2A Loss, and CDKN2B Loss are the most common alterations in malignant glioma [2].

Top Alterations in Malignant Glioma

Significant Genes in Malignant Glioma

AKT3 +

APC +

BRAF +

CCND1 +

CCND2 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2B +

CDKN2C +

CTDNEP1 +

CTNNB1 +

DDX3X +

EGFR +

ERBB2 +

ERBB4 +

GLI2 +

H3F3A +

IDH1 +

IDH2 +

KDM6A +

KIT +

KMT2C +

KMT2D +

LRP1B +

MDM4 +

MLH1 +

MSH2 +

MSH6 +

MTOR +

MYC +

MYCL +

MYCN +

NF1 +

OTX2 +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3R1 +

PMS2 +

PPM1D +

PTCH1 +

PTEN +

PVT1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
GLIOMA, MALIGNANT, Malignant Glial Tumor, Malignant Glial Neoplasm, Malignant Neuroglial Neoplasm, Malignant Neuroglial Tumor
Parent(s)
Malignant Central Nervous System Neoplasm
Children
WHO Grade III Glioma, High-Grade Glioma, NOS, Diffuse Midline Glioma, H3 K27M-Mutant, and High Grade Astrocytic Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.