Associated Genetic Biomarkers

Overview

NCI Definition: This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma. [1]

Mature T-cell and NK-cell non-hodgkin lymphomas most frequently harbor alterations in TET2, DNMT3A, KMT2D, RHOA, and TP53 [2].

Most Commonly Altered Genes in Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

TET2 Mutation, TET2 Frameshift, KMT2D Mutation, TET2 c.5533-c.6005 Missense, and TET2 c.5524-c.5762 Missense are the most common alterations in mature T-cell and NK-cell non-hodgkin lymphoma [2].

Top Alterations in Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Significant Genes in Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

ABL1 +

AFF1 +

ALK +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BCR +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

DEK +

ELL +

ERCC2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FLT3 +

HDAC1 +

HDAC2 +

KMT2A +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLH1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MUTYH +

NBN +

NPM1 +

NUP214 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

POLD1 +

POLE +

POLQ +

PPP2R1A +

PPP2R2A +

PRKDC +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RPN1 +

SLX4 +

STAG2 +

STK11 +

TCF3 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Mature T-Cell Non-Hodgkin's Lymphoma, PTCL, peripheral T-cell lymphoma, Mature T-and NK-Cell Lymphoma, Mature T-Cell and NK-Cell Non-Hodgkin's Lymphoma, Mature T-Cell and NK-Cell Lymphoma, Peripheral T-Cell Lymphoma, mature T-cell lymphoma
Parent(s)
T-Cell Non-Hodgkin Lymphoma
Children
Nasal Type Extranodal NK/T-Cell Lymphoma, Systemic EBV-Positive T-Cell Lymphoma of Childhood, Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Anaplastic Large Cell Lymphoma, Follicular T-Cell Lymphoma, Enteropathy-Associated T-Cell Lymphoma, NK-Cell Lymphoma, Unclassifiable, Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma, Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma, Mature T-Cell and NK-Cell Lymphoma/Leukemia, Adult T-Cell Leukemia/Lymphoma, Peripheral T-Cell Lymphoma, Peripheral T-Cell Lymphoma, Unclassifiable, Peripheral T-Cell Lymphoma, NOS, Primary Cutaneous T Cell Non-Hodgkin Lymphoma, Angioimmunoblastic T-Cell Lymphoma, Sezary Syndrome, Hepatosplenic T-Cell Lymphoma, and Nodal Peripheral T-Cell Lymphoma with TFH Phenotype

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.