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Mixed Phenotype Acute Leukemia, B/Myeloid, NOS
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Associated Genetic Biomarkers
Overview
NCI Definition: A rare mixed phenotype acute leukemia in which the blasts express B-lymphoid and myeloid lineage markers but are negative for MLL translocation and t(9;22)(q34;q11.2) translocation. The prognosis is usually unfavorable. [1]
Mixed phenotype acute leukemia, B/myeloid, NOSs most frequently harbor alterations in TP53, TET2, RUNX1, DNMT3A, and FLT3 [2].
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 8 Mutation, and TET2fs are the most common alterations in mixed phenotype acute leukemia, B/myeloid, NOS [2].
Significant Genes in Mixed Phenotype Acute Leukemia, B/Myeloid, NOS
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.