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Myelofibrosis Transformation in Essential Thrombocythemia
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Associated Genetic Biomarkers
Overview
NCI Definition: Myelofibrosis that develops in a patient with history of essential thrombocythemia. [1]
Myelofibrosis transformation in essential thrombocythemias most frequently harbor alterations in CALR, JAK2, ASXL1, TET2, and DNMT3A [2].
CALR Mutation, JAK2 V617F, JAK2 Mutation, JAK2 Exon 14 Mutation, and CALR L367fs are the most common alterations in myelofibrosis transformation in essential thrombocythemia [2].
Significant Genes in Myelofibrosis Transformation in Essential Thrombocythemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.