Overview

NCI Definition: Myelofibrosis that develops in a patient with history of essential thrombocythemia. [1]

Significant Genes in Myelofibrosis Transformation in Essential Thrombocythemia

AFF1 +

ELL +

IDH1 +

IDH2 +

JAK2 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NRIP3 +

RPN1 +

Disease Details

Synonyms
Post- Essential Thrombocythemia Myelofibrosis
Parent(s)
Secondary Myelofibrosis
OncoTree Name
Essential Thrombocythemia Myelofibrosis
OncoTree Code
ETMF

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.