Overview

NCI Definition: A group of central nervous system neoplasms with a variable amount of neuronal and, less consistently, glial differentiation. They occur at a low frequency and usually carry a favorable prognosis. Representative examples include dysplastic cerebellar gangliocytoma, desmoplastic infantile ganglioglioma, desmoplastic infantile astrocytoma, and dysembryoplastic neuroepithelial tumor. (Adapted from WHO) [1]

Significant Genes in Neuronal and Mixed Neuronal-Glial Tumors

ARAF +

BRAF +

CRKL +

FGFR1 +

FGFR2 +

FGFR3 +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MYB +

MYBL1 +

NF1 +

NF2 +

NRAS +

PTPN1 +

RAF1 +

SOS1 +

SRC +

Disease Details

Synonyms
Neuronal and Glio-Neuronal Tumor, Neuronal and Glio-Neuronal Neoplasm, Neuronal and Mixed Neuronal-Glial Tumor
Parent(s)
Neuroepithelial Neoplasm
Children
Extraventricular Neurocytoma, Papillary Glioneuronal Tumor, Dysplastic Cerebellar Gangliocytoma, Rosette-Forming Glioneuronal Tumor, Desmoplastic Infantile Astrocytoma, Central Neurocytoma, Anaplastic Ganglioglioma, Cerebellar Liponeurocytoma, Dysembryoplastic Neuroepithelial Tumor, Desmoplastic Infantile Ganglioglioma, Gangliocytoma, and Ganglioglioma
OncoTree Name
Miscellaneous Neuroepithelial Tumor
OncoTree Code
MNET

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.