Diseases /
Pilomyxoid Astrocytoma
Back to Diseases List
Associated Genetic Biomarkers
Overview
NCI Definition: An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive. [1]
Pilomyxoid astrocytomas most frequently harbor alterations in BRAF, KIAA1549, NF1, FGFR1, and ZNF703 [2].
KIAA1549-BRAF Fusion, KIAA1549 Fusion, BRAF-KIAA1549 Fusion, BRAF V600E, and BRAF Mutation are the most common alterations in pilomyxoid astrocytoma [2].
Clinical Trials
Significant Genes in Pilomyxoid Astrocytoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.