NCI Definition: An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive. 
Pilomyxoid astrocytomas most frequently harbor alterations in BRAF .
There are 2 clinical trials for pilomyxoid astrocytoma, of which 2 are open and 0 are completed or closed. Of the trials that contain pilomyxoid astrocytoma as an inclusion criterion, 2 are phase 1/phase 2 (2 open).
Bevacizumab, carboplatin, and cetuximab are the most common interventions in pilomyxoid astrocytoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.