Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the prostate gland. It is one of the most common malignant tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone and a minority occurs in the central or the transitional zone of the prostate gland. Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival. Several grading systems have been proposed, of which the Gleason system is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [1]

Prostate adenocarcinomas most frequently harbor alterations in TP53, TMPRSS2, ERG, PTEN, and AR [2].

Most Commonly Altered Genes in Prostate Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in prostate adenocarcinoma [2].

Top Alterations in Prostate Adenocarcinoma

Significant Genes in Prostate Adenocarcinoma

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

ERBB2 +

ERCC3 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

GEN1 +

HDAC1 +

HDAC2 +

MCPH1 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS2 +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

STAG2 +

STK11 +

XRCC1 +

Disease Details

Synonyms
Adenocarcinoma of Prostate, Adenocarcinoma of the Prostate
Parent(s)
Prostate Carcinoma
Children
Acinar Prostate Adenocarcinoma, Lymphoepithelioma-Like Variant, Acinar Prostate Adenocarcinoma, Acinar Prostate Adenocarcinoma, Signet Ring Variant, and Acinar Prostate Mucinous Adenocarcinoma
OncoTree Name
Prostate Adenocarcinoma
OncoTree Code
PRAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.