Overview

NCI Definition: Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001) [1]

T-cell acute lymphoblastic leukemias most frequently harbor alterations in WT1, NOTCH1, EZH2, BCORL1, and USP7 [2].

Most Commonly Altered Genes in T-Cell Acute Lymphoblastic Leukemia

WT1fs, NOTCH1 Mutation, NOTCH1 Missense, EZH2 Mutation, and EZH2 Exon 19 Mutation are the most common alterations in T-cell acute lymphoblastic leukemia [2].

Top Alterations in T-Cell Acute Lymphoblastic Leukemia

Significant Genes in T-Cell Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

BCR +

CBL +

CEP72 +

CRLF2 +

DEK +

ELL +

EPOR +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KMT2A +

KRAS +

LYN +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NRAS +

NRIP3 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PDGFRA +

PDGFRB +

PTPN11 +

RPN1 +

RUNX1 +

SH2B3 +

TP53 +

TYK2 +

Disease Details

Synonyms
Bone marrow leukemia T cell acute (T-ALL)
Parent(s)
T-Cell Lymphoblastic Leukemia/Lymphoma
Children
Early T-Cell Acute Lymphoblastic Leukemia and Adult T-Cell Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.