Overview

NCI Definition: Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females. (WHO, 2001) [1]

T-cell acute lymphoblastic leukemias most frequently harbor alterations in NOTCH1 [2].

Most Commonly Altered Genes in T-Cell Acute Lymphoblastic Leukemia

NOTCH1 Mutation and NOTCH1 Missense are the most common alterations in T-cell acute lymphoblastic leukemia [2].

Top Alterations in T-Cell Acute Lymphoblastic Leukemia

Significant Genes in T-Cell Acute Lymphoblastic Leukemia

ABL1 +

AFF1 +

ASXL1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NUP214 +

RPN1 +

RUNX1 +

TP53 +

Disease Details

Parent(s)
T-Cell Lymphoblastic Leukemia/Lymphoma
Children
Adult T-Cell Acute Lymphoblastic Leukemia and Early T-Cell Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.