Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the vaginal epithelium. The majority of vaginal carcinomas are squamous cell carcinomas. [1]

Vaginal carcinomas most frequently harbor alterations in TP53, KRAS, KMT2D, XRCC1, and TNFRSF14 [2].

Most Commonly Altered Genes in Vaginal Carcinoma

TP53 Mutation, KRAS Mutation (somatic), KRAS Mutation (germline), KRAS Mutation, and XRCC1 Q625H are the most common alterations in vaginal carcinoma [2].

Top Alterations in Vaginal Carcinoma

Significant Genes in Vaginal Carcinoma

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

MYC +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS2 +

PPP2R1A +

PPP2R2A +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RB1 +

SLX4 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Cancer of Vagina, Carcinoma of the Vagina, Vagina Carcinoma, Cancer of the Vagina, Vaginal Cancer, Vaginal cancer, NOS, Vagina Cancer, Carcinoma of Vagina
Parent(s)
Malignant Vaginal Neoplasm
Children
Poorly Differentiated Vaginal Carcinoma, Vaginal Adenocarcinoma, and Vaginal Squamous Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.