Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the vulva. It usually affects elderly women but has been observed in premenopausal women as well. The most frequently seen histologic type is squamous cell carcinoma. The most common site of involvement is the labia majora. In many cases, the development of vulvar cancer is preceded by condyloma or squamous dysplasia. [1]

Significant Genes in Vulvar Carcinoma

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MRE11A +

MSH2 +

MSH6 +

MUTYH +

MYC +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS2 +

PPP2R1A +

PPP2R2A +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RB1 +

SLX4 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Carcinoma of the Vulva, Vulva Cancer, Cancer of the Vulva, Carcinoma of Vulva, Cancer of Vulva, Vulvar Cancer, Vulvar cancer, NOS, Vulva Carcinoma
Parent(s)
Malignant Vulvar Neoplasm
Children
Vulvar Adenocarcinoma, Vulvar Basal Cell Carcinoma, Labia Majora Carcinoma, Labia Minora Carcinoma, Bartholin Gland Carcinoma, and Vulvar Squamous Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.