Overview

Location [1]
Xp22.2
Protein [2]
Fanconi anemia group B protein
Synonyms [1]
FAAP95, FAB, FA2, FACB, FAAP90

Fanconi anemia complementation group B (FANCB) is a gene that encodes a protein that functions in DNA repair. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as endometrial cancer, sarcomas, and stomach cancer.

FANCB is altered in 1.65% of all cancers with lung adenocarcinoma, melanoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FANCB GENIE Cases - Top Diseases

The most common alterations in FANCB are FANCB Mutation (1.57%), FANCB L43I (0.07%), FANCB Loss (0.04%), FANCB Q524E (0.04%), and FANCB Amplification (0.05%) [3].

FANCB GENIE Cases - Top Alterations

Significance of FANCB in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Non-Small Cell Lung Carcinoma +

Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Squamous Cell Lung Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Cholangiocarcinoma +

Gastrointestinal Stromal Tumor +

Esophageal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Osteosarcoma +

Mantle Cell Lymphoma +

Melanoma +

Gastric Adenocarcinoma +

Malignant Gastric Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Biliary Tract Carcinoma +

Leiomyosarcoma +

Malignant Ovarian Epithelial Tumor +

Cancer +

Diffuse Large B-Cell Lymphoma +

Malignant Esophagogastric Neoplasm +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Bile Duct Adenocarcinoma +

Bladder Urothelial Carcinoma +

Esophageal Adenocarcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Ewing Sarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Mesothelioma +

Malignant Small Intestinal Neoplasm +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Rhabdomyosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.