Overview

Location [1]
Xp11.3
Pathway
MAP kinase signaling
Protein [2]
Serine/threonine-protein kinase A-Raf
Synonyms [1]
PKS2, ARAF1, RAFA1, A-RAF

A-Raf proto-oncogene, serine/threonine kinase (ARAF) is a gene that encodes a protein serine/threonine kinase. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

ARAF is altered in 1.21% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

ARAF GENIE Cases - Top Diseases

The most common alterations in ARAF are ARAF Mutation (1.16%), ARAF Amplification (0.15%), ARAF Loss (0.10%), ARAF R255Gfs*37 (0.09%), and ARAF P8Lfs*26 (0.04%) [3].

ARAF GENIE Cases - Top Alterations

Significance of ARAF in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Glioma +

Ovarian Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Endometrial Carcinoma +

Cutaneous Melanoma +

Colorectal Carcinoma +

Squamous Cell Lung Carcinoma +

Low Grade Glioma +

Breast Carcinoma +

Renal Cell Carcinoma +

Pancreatic Carcinoma +

Embryonal Rhabdomyosarcoma +

Hepatocellular Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Neurofibromatosis Type 1 +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.