ATM serine/threonine kinase (ATM) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. The protein functions as a cell cycle checkpoint kinase and regulates multiple downstream effectors. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
Modified: December 4, 2015
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