Overview

Location [1]
3q23
Pathway
DNA damage/repair
Protein [2]
Serine/threonine-protein kinase ATR
Synonyms [1]
FCTCS, MEC1, SCKL, FRP1, SCKL1

ATR serine/threonine kinase (ATR) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. The protein functions in the phosphorylation of checkpoint kinase CHK1, RAD17, RAD9, and tumor suppressor protein BRCA1 - proteins that are involved in the cell cycle and DNA damage signaling pathways. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

ATR is altered in 3.38% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

ATR GENIE Cases - Top Diseases

The most common alterations in ATR are ATR Mutation (2.43%), ATR Mutation (germline) (2.43%), ATR Amplification (0.21%), ATR Frameshift (0.17%), and ATR Frameshift (germline) (0.17%) [3].

ATR GENIE Cases - Top Alterations

Significance of ATR in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Cervical Carcinoma +

Non-Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Carcinoma +

Gastric Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Melanoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Head And Neck Carcinoma +

Anal Carcinoma +

Glioblastoma +

Anaplastic Astrocytoma +

Lung Adenocarcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Leiomyosarcoma +

High Grade Ovarian Serous Adenocarcinoma +

Lymphoma +

Sarcoma +

Diffuse Large B-Cell Lymphoma +

Soft Tissue Sarcoma +

Osteosarcoma +

Mesothelioma +

Clear Cell Renal Cell Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.