ATR
ATR serine/threonine kinase (ATR) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. The protein functions in the phosphorylation of checkpoint kinase CHK1, RAD17, RAD9, and tumor suppressor protein BRCA1—proteins that are involved in the cell cycle and DNA damage signaling pathways. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.