Overview

Location [1]
17q12
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 12
Synonyms [1]
CRK7, CRKR, CRKRS

Cyclin-dependent kinase 12 (CDK12) is a gene that encodes a protein that functions in the phosphorylation of the C-terminal of the large subunit of RNA polymerase II, the maintenance of genomic stability, and the process of DNA repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CDK12 is altered in 4.30% of all cancers with breast carcinoma, colorectal adenocarcinoma, non-small cell lung carcinoma, prostate cancer, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

CDK12 GENIE Cases - Top Diseases

The most common alterations in CDK12 are CDK12 Amplification (1.61%), CDK12 Mutation (1.60%), CDK12 T1463Nfs*50 (0.03%), CDK12 G1461Afs*38 (0.03%), and CDK12 R663H (0.02%) [3].

CDK12 GENIE Cases - Top Alterations

Significance of CDK12 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Hodgkin Lymphoma +

Gastric Carcinoma +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Pancreatic Carcinoma +

Fallopian Tube Carcinoma +

Esophageal Adenocarcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Melanoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Anal Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Uveal Melanoma +

Head And Neck Carcinoma +

Squamous Cell Lung Carcinoma +

Lung Adenocarcinoma +

Glioblastoma +

Leiomyosarcoma +

Pancreatic Adenocarcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Sarcoma +

Clear Cell Renal Cell Carcinoma +

Renal Cell Carcinoma +

Anaplastic Astrocytoma +

Diffuse Large B-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mesothelioma +

Osteosarcoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Primary Peritoneal Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.