Overview

Location [1]
17q12
Pathway
Cell cycle control
Protein [2]
Cyclin-dependent kinase 12
Synonyms [1]
CRKR, CRKRS, CRK7

Cyclin-dependent kinase 12 (CDK12) is a gene that encodes a protein that functions in the phosphorylation of the C-terminal of the large subunit of RNA polymerase II, the maintenance of genomic stability, and the process of DNA repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CDK12 is altered in 3.53% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

CDK12 GENIE Cases - Top Diseases

The most common alterations in CDK12 are CDK12 Amplification (1.61%), CDK12 Mutation (1.60%), CDK12 Frameshift (0.32%), CDK12 Nonsense (0.17%), and CDK12 T1463Nfs*50 (0.03%) [3].

CDK12 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CDK12 in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Non-Small Cell Lung Carcinoma +

Fallopian Tube Carcinoma +

Colorectal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Endometrial Carcinoma +

Bladder Urothelial Carcinoma +

Gastric Adenocarcinoma +

Cholangiocarcinoma +

Pancreatic Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Small Intestinal Neoplasm +

Bladder Carcinoma +

Melanoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Intestinal Neoplasm +

Malignant Ovarian Epithelial Tumor +

Glioblastoma +

Pancreatic Adenocarcinoma +

Renal Cell Carcinoma +

Kidney Carcinoma +

Sarcoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Anaplastic Astrocytoma +

Diffuse Large B-Cell Lymphoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Leiomyosarcoma +

Lymphoma +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Osteosarcoma +

Penile Carcinoma +

Prostate Small Cell Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.