Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
Cell cycle control
Protein [2]
Cyclin-dependent kinase 12
Synonyms [1]

Cyclin-dependent kinase 12 (CDK12) is a gene that encodes a protein that functions in the phosphorylation of the C-terminal of the large subunit of RNA polymerase II, the maintenance of genomic stability, and the process of DNA repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CDK12 is altered in 3.43% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

CDK12 GENIE Cases - Top Diseases

The most common alterations in CDK12 are CDK12 Mutation (1.81%), CDK12 Amplification (2.00%), CDK12 Nonsense (0.25%), CDK12 Fusion (0.13%), and CDK12 Loss (0.03%) [3].

CDK12 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CDK12 in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Colorectal Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Endometrial Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Melanoma +

High Grade Ovarian Serous Adenocarcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Bladder Urothelial Carcinoma +

Bladder Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Gastrointestinal Stromal Tumor +

Non-Hodgkin Lymphoma +

Clear Cell Renal Cell Carcinoma +

Osteosarcoma +

Prostate Small Cell Carcinoma +

Malignant Esophagogastric Neoplasm +

Penile Carcinoma +

Gallbladder Carcinoma +

Malignant Gastric Neoplasm +

High Grade Fallopian Tube Serous Adenocarcinoma +

Malignant Uterine Neoplasm +

Pancreatic Ductal Adenocarcinoma +

Malignant Small Intestinal Neoplasm +

Anal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Malignant Intestinal Neoplasm +

Colorectal Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Neuroblastoma +

Biliary Tract Carcinoma +

Lung Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Glioblastoma +

Glioma +

Malignant Central Nervous System Neoplasm +

Ampulla Of Vater Carcinoma +

Bile Duct Adenocarcinoma +

Bile Duct Carcinoma +

Cholangiocarcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Leiomyosarcoma +

Multiple Myeloma +

Anaplastic Astrocytoma +

Diffuse Large B-Cell Lymphoma +

Ewing Sarcoma +

Sarcoma +

Lymphoma +

Mantle Cell Lymphoma +

Renal Cell Carcinoma +

Malignant Mesothelioma +

B-Cell Non-Hodgkin Lymphoma +

Bronchogenic Carcinoma +

Medulloblastoma +

Ovarian Clear Cell Adenocarcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Rhabdomyosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.