Overview

Location [1]
11q24.2
Pathway
Cell cycle control
Protein [2]
Serine/threonine-protein kinase Chk1
Synonyms [1]
CHK1

Checkpoint kinase 1 (CHEK1) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the cell cycle arrest response to DNA damage or unreplicated DNA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CHEK1 is altered in 0.80% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, breast carcinoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

CHEK1 GENIE Cases - Top Diseases

The most common alterations in CHEK1 are CHEK1 Mutation (0.48%), CHEK1 Mutation (germline) (0.48%), CHEK1 Loss (0.07%), CHEK1 T226Hfs*14 (0.05%), and CHEK1 Amplification (0.03%) [3].

CHEK1 GENIE Cases - Top Alterations

Significance of CHEK1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Fallopian Tube Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Pancreatic Adenocarcinoma +

Urothelial Carcinoma +

Non-Hodgkin Lymphoma +

Primary Peritoneal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Gastric Carcinoma +

Cholangiocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Endometrial Carcinoma +

Diffuse Large B-Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Uveal Melanoma +

Leiomyosarcoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Pancreatic Carcinoma +

Bladder Carcinoma +

Renal Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Clear Cell Renal Cell Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mesothelioma +

Multiple Myeloma +

Osteosarcoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Soft Tissue Sarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.