Biomarkers /
CHEK1
Overview
Checkpoint kinase 1 (CHEK1) is a gene that encodes a protein that is a member of the serine/threonine kinase family. The protein functions in the cell cycle arrest response to DNA damage or unreplicated DNA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
CHEK1 is altered in 0.79% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and melanoma having the greatest prevalence of alterations [3].
The most common alterations in CHEK1 are CHEK1 Mutation (0.54%), CHEK1 Loss (0.12%), CHEK1 Amplification (0.06%), CHEK1 K225E (0.05%), and CHEK1 N356H (0.07%) [3].
Biomarker-Directed Therapies
Clinical Trials
Significance of CHEK1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.