Overview

Location [1]
22q11.21
Pathways
MAP kinase signaling, PI3K/AKT1/MTOR
Protein [2]
Crk-like protein
Synonyms [1]
-

V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a gene that encodes a SH2 and SH3 domain containing protein kinase. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CRKL is altered in 0.70% of all cancers with lung adenocarcinoma, high grade ovarian serous adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

CRKL GENIE Cases - Top Diseases

The most common alterations in CRKL are CRKL Amplification (0.50%), CRKL Mutation (0.27%), CRKL Loss (0.06%), CRKL R164Q (0.02%), and CRKL P135S (0.01%) [3].

CRKL GENIE Cases - Top Alterations

Significance of CRKL in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Ovarian Carcinoma +

Glioma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Neuroblastoma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Cutaneous Melanoma +

Soft Tissue Sarcoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Cancer +

Pancreatic Carcinoma +

Prostate Carcinoma +

Aggressive Systemic Mastocytosis +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Embryonal Rhabdomyosarcoma +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Glioblastoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Liposarcoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Mast Cell Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Neurofibromatosis Type 1 +

Osteosarcoma +

Pecoma +

Peritoneal Mesothelioma +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Small Cell Lung Carcinoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.