Location [1]
PI3K/AKT1/MTOR, MAP kinase signaling
Protein [2]
Crk-like protein
Synonyms [1]

V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a gene that encodes a SH2 and SH3 domain containing protein kinase. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CRKL is altered in 0.82% of all cancers with lung adenocarcinoma, high grade ovarian serous adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

CRKL GENIE Cases - Top Diseases

The most common alterations in CRKL are CRKL Amplification (0.51%), CRKL Mutation (0.30%), CRKL Loss (0.07%), CRKL R164Q (0.02%), and CRKL X104_splice (0.06%) [3].

CRKL GENIE Cases - Top Alterations

Significance of CRKL in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Ovarian Carcinoma +

Glioma +

Renal Cell Carcinoma +

Hepatocellular Carcinoma +

Thyroid Gland Carcinoma +

Low Grade Glioma +

Myelodysplastic Syndromes +

Embryonal Rhabdomyosarcoma +

Cutaneous Melanoma +

Undifferentiated Pleomorphic Sarcoma +

Peritoneal Mesothelioma +

Endometrial Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Liposarcoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Chondrosarcoma +

Osteosarcoma +

Urothelial Carcinoma +

Ewing Sarcoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Cancer +

Multiple Myeloma +

Gastric Adenocarcinoma +

Astrocytic Tumor +

Diffuse Glioma +

Neuroblastoma +

Pancreatic Carcinoma +

Hematologic And Lymphocytic Disorder +

Prostate Carcinoma +

Hematopoietic And Lymphoid System Neoplasm +

Hematopoietic And Lymphoid Malignancy +

Acute Myeloid Leukemia +

Myeloid Neoplasm +

Aggressive Systemic Mastocytosis +

Chronic Myelomonocytic Leukemia +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Ganglioglioma +

Low-Grade Neuroepithelial Tumor, NOS +

Mast Cell Leukemia +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Pecoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Rhabdoid Tumor +

Schwannoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.