Overview

Location [1]
22q11.21
Pathways
MAP kinase signaling, PI3K/AKT1/MTOR
Protein [2]
Crk-like protein
Synonyms [1]
-

V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a gene that encodes a SH2 and SH3 domain containing protein kinase. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CRKL is altered in 0.82% of all cancers with non-small cell lung carcinoma, melanoma, sarcoma, ovarian neoplasm, and breast carcinoma having the greatest prevalence of alterations [3].

CRKL GENIE Cases - Top Diseases

The most common alterations in CRKL are CRKL Amplification (0.50%), CRKL Mutation (0.27%), CRKL Mutation (somatic) (0.27%), CRKL Loss (0.06%), and CRKL R164Q (0.02%) [3].

CRKL GENIE Cases - Top Alterations

Significance of CRKL in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Glioma +

Melanoma +

Endometrial Carcinoma +

Squamous Cell Lung Carcinoma +

Neuroblastoma +

Colorectal Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Neurofibromatosis Type 1 +

Rhabdomyosarcoma +

Peritoneal Mesothelioma +

Soft Tissue Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Thyroid Gland Carcinoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Glioblastoma +

Prostate Carcinoma +

Cancer +

Hepatocellular Carcinoma +

Malignant Peripheral Nerve Sheath Tumor +

Multiple Myeloma +

Ovarian Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Rhabdoid Tumor +

Schwannoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.