Overview

Location [1]
22q11.21
Pathways
PI3K/AKT1/MTOR, MAP kinase signaling
Synonyms [1]
-

V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a gene that encodes a SH2 and SH3 domain containing protein kinase. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of CRKL in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Glioma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Myelodysplastic Syndromes +

Ovarian Carcinoma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Acute Myeloid Leukemia +

Aggressive Systemic Mastocytosis +

Astrocytic Tumor +

Cancer +

Chondrosarcoma +

Chronic Myelomonocytic Leukemia +

Classical Hodgkin Lymphoma +

Cutaneous Melanoma +

Desmoid-Type Fibromatosis +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Ewing Sarcoma +

Gangliocytoma +

Ganglioglioma +

Gastric Adenocarcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Liposarcoma +

Low-Grade Neuroepithelial Tumor, NOS +

Malignant Peripheral Nerve Sheath Tumor +

Mast Cell Leukemia +

Multiple Myeloma +

Myeloid Neoplasm +

Neuroblastoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Osteosarcoma +

Pecoma +

Pancreatic Carcinoma +

Peritoneal Mesothelioma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Prostate Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.