Overview

Location [1]
Xp22.2
Protein [2]
Fanconi anemia group B protein
Synonyms [1]
FA2, FAAP95, FAAP90, FAB, FACB

Fanconi anemia complementation group B (FANCB) is a gene that encodes a protein that functions in DNA repair. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as endometrial cancer, sarcomas, and stomach cancer.

FANCB is altered in 1.70% of all cancers with non-small cell lung carcinoma, breast carcinoma, colorectal adenocarcinoma, melanoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

FANCB GENIE Cases - Top Diseases

The most common alterations in FANCB are FANCB Mutation (0.22%), FANCB Mutation (germline) (0.22%), FANCB L43I (0.01%), FANCB N10K (0.01%), and FANCB Amplification (0.00%) [3].

FANCB GENIE Cases - Top Alterations

Significance of FANCB in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Urothelial Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Primary Peritoneal Carcinoma +

Mantle Cell Lymphoma +

Endometrial Carcinoma +

Leiomyosarcoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Diffuse Large B-Cell Lymphoma +

Soft Tissue Sarcoma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Clear Cell Renal Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Osteosarcoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Squamous Cell Lung Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.