Overview

Location [1]
9p13.3
Pathway
DNA damage/repair
Protein [2]
Fanconi anemia group G protein
Synonyms [1]
XRCC9, FAG

Fanconi anemia, complementation group G (FANCG) is a gene that encodes a protein that is a member of the Fanconi anemia complementation group. The protein complex functions in the heterogeneous recessive disorder Fanconi anemia that causes cytogenetic instability, hypersensitivity to DNA crosslinking agents, increases chromosomal breakage, and defective DNA repair. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

FANCG is altered in 1.38% of all cancers with non-small cell lung carcinoma, breast carcinoma, colorectal adenocarcinoma, melanoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

FANCG GENIE Cases - Top Diseases

The most common alterations in FANCG are FANCG Mutation (0.53%), FANCG Mutation (germline) (0.53%), FANCG Amplification (0.08%), FANCG A265V (0.01%), and FANCG X494_splice (0.01%) [3].

FANCG GENIE Cases - Top Alterations

Significance of FANCG in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Small Cell Lung Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Cholangiocarcinoma +

Cervical Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Mesothelioma +

Soft Tissue Sarcoma +

Non-Small Cell Lung Carcinoma +

Lung Adenocarcinoma +

Bladder Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Clear Cell Renal Cell Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Diffuse Large B-Cell Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Leiomyosarcoma +

Mantle Cell Lymphoma +

Multiple Myeloma +

Osteosarcoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.