Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
14q21.2
Protein [2]
Fanconi anemia group M protein
Synonyms [1]
KIAA1596, POF15, FAAP250, SPGF28

Fanconi anemia complementation group M (FANCM) is a gene that encodes a protein that functions in DNA repair. Missense mutations, synonymous mutations, frameshift deletions, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, endometrial cancer, and stomach cancer.

FANCM is altered in 5.06% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, glioblastoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FANCM GENIE Cases - Top Diseases

The most common alterations in FANCM are FANCM Mutation (4.93%), FANCM Nonsense (0.45%), FANCM Frameshift (0.37%), FANCM V1336fs (0.16%), and FANCM I259V (0.11%) [3].

FANCM GENIE Cases - Top Alterations

Significance of FANCM in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Soft Tissue Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Esophageal Carcinoma +

Head And Neck Carcinoma +

Non-Hodgkin Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Gastrointestinal Stromal Tumor +

Osteosarcoma +

Mantle Cell Lymphoma +

Melanoma +

Anal Carcinoma +

Biliary Tract Carcinoma +

Bladder Urothelial Carcinoma +

Colorectal Adenocarcinoma +

Rhabdomyosarcoma +

Malignant Intestinal Neoplasm +

Esophageal Adenocarcinoma +

Multiple Myeloma +

Cancer +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Malignant Esophagogastric Neoplasm +

Glioma +

Clear Cell Renal Cell Carcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Mesothelioma +

Medulloblastoma +

Invasive Breast Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Neuroblastoma +

Malignant Ovarian Epithelial Tumor +

Gastric Adenocarcinoma +

Malignant Gastric Neoplasm +

Leiomyosarcoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Ampulla Of Vater Carcinoma +

Ewing Sarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Small Intestinal Neoplasm +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.