Overview

Location [1]
14q21.2
Protein [2]
Fanconi anemia group M protein
Synonyms [1]
FAAP250, KIAA1596

Fanconi anemia complementation group M (FANCM) is a gene that encodes a protein that functions in DNA repair. Missense mutations, synonymous mutations, frameshift deletions, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, endometrial cancer, and stomach cancer.

FANCM is altered in 3.86% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, breast carcinoma, malignant glioma, and melanoma having the greatest prevalence of alterations [3].

FANCM GENIE Cases - Top Diseases

The most common alterations in FANCM are FANCM Mutation (0.67%), FANCM Mutation (germline) (0.67%), FANCM Frameshift (0.04%), FANCM Frameshift (germline) (0.04%), and FANCM V1336Lfs*2 (0.02%) [3].

FANCM GENIE Cases - Top Alterations

Significance of FANCM in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Urothelial Carcinoma +

Cholangiocarcinoma +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Mantle Cell Lymphoma +

Endometrial Carcinoma +

Anal Carcinoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Mesothelioma +

Squamous Cell Lung Carcinoma +

Diffuse Large B-Cell Lymphoma +

Soft Tissue Sarcoma +

Clear Cell Renal Cell Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Leiomyosarcoma +

High Grade Ovarian Serous Adenocarcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Multiple Myeloma +

Osteosarcoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.