Overview

Location [1]
11q21
Pathway
Chromatin remodeling/DNA methylation
Synonyms [1]
ATLD, MRE11B, HNGS1, MRE11

MRE11 meiotic recombination 11 homolog A (MRE11) is a gene that encodes a nuclear protein that functions in homologous recombination, the maintenance of telomere length, and DNA double-strand break repair. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

MRE11A is altered in 1.30% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, melanoma, breast carcinoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

MRE11A GENIE Cases - Top Diseases

The most common alterations in MRE11A are MRE11A Mutation (0.78%), MRE11A Mutation (germline) (0.78%), MRE11A Frameshift (0.10%), MRE11A Frameshift (germline) (0.10%), and MRE11A Amplification (0.08%) [3].

MRE11A GENIE Cases - Top Alterations

Significance of MRE11A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Pancreatic Adenocarcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Urothelial Carcinoma +

Cholangiocarcinoma +

Gastric Carcinoma +

Primary Peritoneal Carcinoma +

Penile Carcinoma +

Endometrial Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Anal Carcinoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Leiomyosarcoma +

Soft Tissue Sarcoma +

Clear Cell Renal Cell Carcinoma +

Pancreatic Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mesothelioma +

Multiple Myeloma +

Osteosarcoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.