Biomarkers /
NBN
Overview
Nibrin (NBN) is a gene that encodes a protein that is a member of the MRE11/RAD50 double-strand break repair complex and is associated with Nijmegen breakage syndrome. Missense mutations, silent mutations, frameshift deletions, and nonsense mutations are observed in cancers such as colon cancer, stomach cancer, and endometrial cancer.
Clinical Trials
Significance of NBN in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.