Overview

Location [1]
16p12.2
Pathway
DNA damage/repair
Protein [2]
Partner and localizer of BRCA2
Synonyms [1]
PNCA3, FANCN

Partner and localizer of BRCA2 (PALB2) is a gene that encodes a protein that functions in tumor suppression. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

PALB2 is altered in 1.87% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, breast carcinoma, uterine corpus neoplasm, and melanoma having the greatest prevalence of alterations [3].

PALB2 GENIE Cases - Top Diseases

The most common alterations in PALB2 are PALB2 Mutation (1.76%), PALB2 Mutation (germline) (1.76%), PALB2 Frameshift (0.15%), PALB2 Frameshift (germline) (0.15%), and PALB2 Amplification (0.07%) [3].

PALB2 GENIE Cases - Top Alterations

Significance of PALB2 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Pancreatic Adenocarcinoma +

Fallopian Tube Carcinoma +

Urothelial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Cholangiocarcinoma +

Gastric Carcinoma +

Cervical Carcinoma +

Mantle Cell Lymphoma +

Anal Carcinoma +

Endometrial Carcinoma +

Bladder Carcinoma +

Esophageal Adenocarcinoma +

Diffuse Large B-Cell Lymphoma +

Lung Adenocarcinoma +

Osteosarcoma +

Non-Small Cell Lung Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Clear Cell Renal Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Renal Cell Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Leiomyosarcoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Mesothelioma +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.