Overview

Location [1]
15q15.1
Pathway
DNA damage/repair
Protein [2]
DNA repair protein RAD51 homolog 1
Synonyms [1]
HsRad51, HRAD51, RECA, FANCR, MRMV2, RAD51A, HsT16930, BRCC5

RAD51 recombinase (RAD51) is a gene that encodes a protein that functions in homologous recombination and DNA repair. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and cancers of the urinary tract.

RAD51 is altered in 0.47% of all cancers with breast carcinoma, melanoma, colorectal adenocarcinoma, non-small cell lung carcinoma, and sarcoma having the greatest prevalence of alterations [3].

RAD51 GENIE Cases - Top Diseases

The most common alterations in RAD51 are RAD51 Mutation (0.20%), RAD51 Mutation (germline) (0.20%), RAD51 Loss (0.10%), RAD51 Amplification (0.03%), and RAD51 A224G (0.01%) [3].

RAD51 GENIE Cases - Top Alterations

Significance of RAD51 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Urothelial Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Pancreatic Adenocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Gastric Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Anal Carcinoma +

Bladder Carcinoma +

Leiomyosarcoma +

Diffuse Large B-Cell Lymphoma +

Mesothelioma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Lung Adenocarcinoma +

Clear Cell Renal Cell Carcinoma +

Pancreatic Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Multiple Myeloma +

Osteosarcoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.