Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
DNA damage/repair
Protein [2]
DNA repair protein RAD51 homolog 1
Synonyms [1]
RAD51A, BRCC5, HsT16930, FANCR, HsRad51, MRMV2, RECA, HRAD51

RAD51 recombinase (RAD51) is a gene that encodes a protein that functions in homologous recombination and DNA repair. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and cancers of the urinary tract.

RAD51 is altered in 0.65% of all cancers with lung adenocarcinoma, glioblastoma, conventional glioblastoma multiforme, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

RAD51 GENIE Cases - Top Diseases

The most common alterations in RAD51 are RAD51 Mutation (0.29%), RAD51 Loss (0.16%), RAD51 Amplification (0.03%), RAD51 Nonsense (0.03%), and RAD51 A224G (0.09%) [3].

RAD51 GENIE Cases - Top Alterations

Significance of RAD51 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Adenocarcinoma +

Small Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Urothelial Carcinoma +

Endometrial Carcinoma +

Melanoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Soft Tissue Sarcoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Bladder Urothelial Carcinoma +

Non-Hodgkin Lymphoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Squamous Cell Lung Carcinoma +

Head And Neck Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Osteosarcoma +

Diffuse Large B-Cell Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Anal Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Rhabdomyosarcoma +

Leiomyosarcoma +

Mantle Cell Lymphoma +

Multiple Myeloma +

Malignant Small Intestinal Neoplasm +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Biliary Tract Carcinoma +

Neuroblastoma +

Malignant Esophagogastric Neoplasm +

Glioma +

Malignant Central Nervous System Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Gastric Neoplasm +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Ampulla Of Vater Carcinoma +

Ewing Sarcoma +

Malignant Mesothelioma +

Medulloblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.