Overview

Location [1]
14q24.1
Protein [2]
DNA repair protein RAD51 homolog 2
Synonyms [1]
R51H2, REC2, RAD51L1

RAD51B is altered in 0.25% of all cancers with lung adenocarcinoma, cutaneous melanoma, bladder urothelial carcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RAD51B GENIE Cases - Top Diseases

The most common alterations in RAD51B are RAD51B Mutation (0.17%), RAD51B Loss (0.08%), RAD51B Amplification (0.02%), RAD51B Nonsense (0.01%), and RAD51B A137V (0.00%) [3].

RAD51B GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD51B in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Pancreatic Adenocarcinoma +

Urothelial Carcinoma +

Endometrial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Colorectal Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Osteosarcoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

Leiomyosarcoma +

Melanoma +

Bladder Urothelial Carcinoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Adenocarcinoma +

Biliary Tract Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Ewing Sarcoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Mesothelioma +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.