Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
14q24.1
Protein [2]
DNA repair protein RAD51 homolog 2
Synonyms [1]
REC2, R51H2, RAD51L1

RAD51B is altered in 0.42% of all cancers with lung adenocarcinoma, cutaneous melanoma, bladder urothelial carcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

RAD51B GENIE Cases - Top Diseases

The most common alterations in RAD51B are RAD51B Mutation (0.32%), RAD51B Loss (0.15%), RAD51B Amplification (0.05%), RAD51B Fusion (0.01%), and RAD51B P109S (0.01%) [3].

RAD51B GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD51B in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Gastric Carcinoma +

Endometrial Carcinoma +

Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Soft Tissue Sarcoma +

Cervical Carcinoma +

Colorectal Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Esophageal Carcinoma +

Head And Neck Carcinoma +

Gastrointestinal Stromal Tumor +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Osteosarcoma +

Rhabdomyosarcoma +

Leiomyosarcoma +

Melanoma +

Bladder Urothelial Carcinoma +

Mantle Cell Lymphoma +

Ampulla Of Vater Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Neuroblastoma +

Colorectal Adenocarcinoma +

Glioma +

Diffuse Large B-Cell Lymphoma +

Malignant Intestinal Neoplasm +

Malignant Central Nervous System Neoplasm +

Malignant Esophagogastric Neoplasm +

Biliary Tract Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Malignant Ovarian Epithelial Tumor +

Anal Carcinoma +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Ewing Sarcoma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Gastric Neoplasm +

Malignant Mesothelioma +

Malignant Small Intestinal Neoplasm +

Medulloblastoma +

Multiple Myeloma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Renal Cell Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.