Overview

Location [1]
17q22
Protein [2]
DNA repair protein RAD51 homolog 3
Synonyms [1]
RAD51L2, FANCO, BROVCA3, R51H3

RAD 51 paralog C (RAD51C) is a gene that encodes a protein that functions in the homologous recombination and repair of DNA. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as cancers of the biliary tract, endometrial cancer, and intestinal cancer.

RAD51C is altered in 1.20% of all cancers with breast carcinoma, non-small cell lung carcinoma, melanoma, colorectal adenocarcinoma, and malignant glioma having the greatest prevalence of alterations [3].

RAD51C GENIE Cases - Top Diseases

The most common alterations in RAD51C are RAD51C Amplification (0.43%), RAD51C Mutation (0.41%), RAD51C Mutation (germline) (0.41%), RAD51C Frameshift (0.01%), and RAD51C Frameshift (germline) (0.01%) [3].

RAD51C GENIE Cases - Top Alterations

Significance of RAD51C in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Colorectal Carcinoma +

Pancreatic Adenocarcinoma +

Primary Peritoneal Carcinoma +

Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Gastric Carcinoma +

Cholangiocarcinoma +

Endometrial Carcinoma +

Diffuse Large B-Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Osteosarcoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Gastric Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Leiomyosarcoma +

High Grade Ovarian Serous Adenocarcinoma +

Esophageal Adenocarcinoma +

Clear Cell Renal Cell Carcinoma +

Pancreatic Carcinoma +

Renal Cell Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mesothelioma +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.