Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q22
Protein [2]
DNA repair protein RAD51 homolog 3
Synonyms [1]
BROVCA3, RAD51L2, FANCO, R51H3

RAD 51 paralog C (RAD51C) is a gene that encodes a protein that functions in the homologous recombination and repair of DNA. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as cancers of the biliary tract, endometrial cancer, and intestinal cancer.

RAD51C is altered in 0.97% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, invasive breast carcinoma, bladder urothelial carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

RAD51C GENIE Cases - Top Diseases

The most common alterations in RAD51C are RAD51C Amplification (0.43%), RAD51C Mutation (0.41%), RAD51C Nonsense (0.03%), RAD51C Frameshift (0.01%), and RAD51C Loss (0.01%) [3].

RAD51C GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD51C in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Urothelial Carcinoma +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Gastrointestinal Stromal Tumor +

Colorectal Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Osteosarcoma +

Pancreatic Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Neuroblastoma +

Bladder Urothelial Carcinoma +

Melanoma +

Malignant Esophagogastric Neoplasm +

Malignant Intestinal Neoplasm +

Colorectal Adenocarcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Adenocarcinoma +

Biliary Tract Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Ewing Sarcoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Leiomyosarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.