Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q22
Protein [2]
DNA repair protein RAD51 homolog 3
Synonyms [1]
BROVCA3, RAD51L2, FANCO, R51H3

RAD 51 paralog C (RAD51C) is a gene that encodes a protein that functions in the homologous recombination and repair of DNA. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as cancers of the biliary tract, endometrial cancer, and intestinal cancer.

RAD51C is altered in 1.23% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, bladder urothelial carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

RAD51C GENIE Cases - Top Diseases

The most common alterations in RAD51C are RAD51C Mutation (0.59%), RAD51C Amplification (0.69%), RAD51C Nonsense (0.07%), RAD51C Fusion (0.02%), and RAD51C Loss (0.02%) [3].

RAD51C GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD51C in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Endometrial Carcinoma +

Gastric Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Cervical Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Colorectal Carcinoma +

Gastric Adenocarcinoma +

Soft Tissue Sarcoma +

Clear Cell Renal Cell Carcinoma +

Bladder Urothelial Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Osteosarcoma +

Cholangiocarcinoma +

Gastrointestinal Stromal Tumor +

Squamous Cell Lung Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Pancreatic Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Neuroblastoma +

Invasive Breast Carcinoma +

Malignant Small Intestinal Neoplasm +

Melanoma +

Malignant Mesothelioma +

Diffuse Large B-Cell Lymphoma +

Ampulla Of Vater Carcinoma +

Bile Duct Adenocarcinoma +

Malignant Intestinal Neoplasm +

Colorectal Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Malignant Esophagogastric Neoplasm +

Biliary Tract Carcinoma +

Rhabdomyosarcoma +

Multiple Myeloma +

Mesothelioma +

Malignant Gastric Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Leiomyosarcoma +

Renal Cell Carcinoma +

Anal Carcinoma +

Ewing Sarcoma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Low Grade Ovarian Serous Adenocarcinoma +

Mantle Cell Lymphoma +

Ovarian Clear Cell Adenocarcinoma +

Penile Carcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.