Overview

Location [1]
17q12
Protein [2]
DNA repair protein RAD51 homolog 4
Synonyms [1]
BROVCA4, RAD51L3, R51H3, TRAD

RAD51 paralog D (RAD51D) is a gene that encodes a protein that is a member of a protein complex thought to be involved in the early stage of recombinatorial DNA repair. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and urinary tract cancer.

RAD51D is altered in 0.62% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, malignant glioma, and melanoma having the greatest prevalence of alterations [3].

RAD51D GENIE Cases - Top Diseases

The most common alterations in RAD51D are RAD51D Mutation (0.28%), RAD51D Mutation (germline) (0.28%), RAD51D Amplification (0.11%), RAD51D Loss (0.04%), and RAD51D S46C (0.01%) [3].

RAD51D GENIE Cases - Top Alterations

Significance of RAD51D in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Colorectal Carcinoma +

Primary Peritoneal Carcinoma +

Gastric Carcinoma +

Cholangiocarcinoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Endometrial Carcinoma +

Osteosarcoma +

Diffuse Large B-Cell Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Gastric Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Lung Adenocarcinoma +

Leiomyosarcoma +

Esophageal Adenocarcinoma +

Renal Cell Carcinoma +

Clear Cell Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Pancreatic Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.