Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q12
Protein [2]
DNA repair protein RAD51 homolog 4
Synonyms [1]
TRAD, RAD51L3, R51H3, BROVCA4

RAD51 paralog D (RAD51D) is a gene that encodes a protein that is a member of a protein complex thought to be involved in the early stage of recombinatorial DNA repair. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and urinary tract cancer.

RAD51D is altered in 0.50% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, conventional glioblastoma multiforme, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

RAD51D GENIE Cases - Top Diseases

The most common alterations in RAD51D are RAD51D Mutation (0.28%), RAD51D Mutation (germline) (0.28%), RAD51D Mutation (somatic) (0.28%), RAD51D Amplification (0.11%), and RAD51D Loss (0.04%) [3].

RAD51D GENIE Cases - Top Alterations

Significance of RAD51D in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Urothelial Carcinoma +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Osteosarcoma +

Pancreatic Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Melanoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Adenocarcinoma +

Biliary Tract Carcinoma +

Bladder Urothelial Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Ewing Sarcoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Leiomyosarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.