Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q12
Synonyms [1]
R51H3, TRAD, RAD51L3, BROVCA4

RAD51 paralog D (RAD51D) is a gene that encodes a protein that is a member of a protein complex thought to be involved in the early stage of recombinatorial DNA repair. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and urinary tract cancer.

Biomarker-Directed Therapies

Significance of RAD51D in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Non-Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Gastric Adenocarcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Pancreatic Carcinoma +

Soft Tissue Sarcoma +

Bladder Urothelial Carcinoma +

Clear Cell Renal Cell Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Central Nervous System Neoplasm +

Osteosarcoma +

Pancreatic Ductal Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Adenocarcinoma +

Biliary Tract Carcinoma +

Cholangiocarcinoma +

Colorectal Adenocarcinoma +

Diffuse Large B-Cell Lymphoma +

Ewing Sarcoma +

Glioma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Histiocytic Sarcoma +

Invasive Breast Carcinoma +

Juvenile Xanthogranuloma +

Langerhans Cell Histiocytosis +

Leiomyosarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Intestinal Neoplasm +

Malignant Mesothelioma +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Medulloblastoma +

Melanoma +

Multiple Myeloma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Penile Carcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Renal Cell Carcinoma +

Rhabdomyosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.