Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q12
Protein [2]
DNA repair protein RAD51 homolog 4
Synonyms [1]
R51H3, RAD51L3, BROVCA4, TRAD

RAD51 paralog D (RAD51D) is a gene that encodes a protein that is a member of a protein complex thought to be involved in the early stage of recombinatorial DNA repair. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as colon cancer, skin cancer, and urinary tract cancer.

RAD51D is altered in 0.60% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RAD51D GENIE Cases - Top Diseases

The most common alterations in RAD51D are RAD51D Mutation (0.38%), RAD51D Amplification (0.15%), RAD51D Loss (0.09%), RAD51D Nonsense (0.04%), and RAD51D S207L (0.04%) [3].

RAD51D GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD51D in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Adenocarcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Small Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Cervical Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Gastric Adenocarcinoma +

Soft Tissue Sarcoma +

Pancreatic Carcinoma +

Malignant Central Nervous System Neoplasm +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Osteosarcoma +

Head And Neck Carcinoma +

Bladder Urothelial Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Pancreatic Ductal Adenocarcinoma +

Melanoma +

Low Grade Ovarian Serous Adenocarcinoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Glioma +

Diffuse Large B-Cell Lymphoma +

Malignant Small Intestinal Neoplasm +

Neuroblastoma +

Multiple Myeloma +

Invasive Breast Carcinoma +

Malignant Ovarian Epithelial Tumor +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Leiomyosarcoma +

B-Cell Non-Hodgkin Lymphoma +

Biliary Tract Carcinoma +

Malignant Gastric Neoplasm +

Malignant Esophagogastric Neoplasm +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Renal Cell Carcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Ewing Sarcoma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Histiocytic Sarcoma +

Juvenile Xanthogranuloma +

Langerhans Cell Histiocytosis +

Malignant Mesothelioma +

Mantle Cell Lymphoma +

Medulloblastoma +

Ovarian Clear Cell Adenocarcinoma +

Penile Carcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Rhabdomyosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.