Overview

Location [1]
1p34.1
Protein [2]
DNA repair and recombination protein RAD54-like
Synonyms [1]
hHR54, hRAD54, HR54, RAD54A

RAD54L is altered in 0.74% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

RAD54L GENIE Cases - Top Diseases

The most common alterations in RAD54L are RAD54L Mutation (0.57%), RAD54L Amplification (0.09%), RAD54L Nonsense (0.05%), RAD54L Loss (0.03%), and RAD54L Fusion (0.02%) [3].

RAD54L GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD54L in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Clear Cell Renal Cell Carcinoma +

Soft Tissue Sarcoma +

High Grade Ovarian Serous Adenocarcinoma +

Bladder Urothelial Carcinoma +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Cholangiocarcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Gastrointestinal Stromal Tumor +

Non-Hodgkin Lymphoma +

Osteosarcoma +

Penile Carcinoma +

Pancreatic Ductal Adenocarcinoma +

High Grade Fallopian Tube Serous Adenocarcinoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Malignant Small Intestinal Neoplasm +

Melanoma +

Multiple Myeloma +

Uveal Melanoma +

Ampulla Of Vater Carcinoma +

Mantle Cell Lymphoma +

Malignant Gastric Neoplasm +

Neuroblastoma +

Malignant Esophagogastric Neoplasm +

Leiomyosarcoma +

Bile Duct Adenocarcinoma +

Renal Cell Carcinoma +

Biliary Tract Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Malignant Ovarian Epithelial Tumor +

Anal Carcinoma +

Ewing Sarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Mesothelioma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Ovarian Clear Cell Adenocarcinoma +

Primary Peritoneal High Grade Serous Adenocarcinoma +

Rhabdomyosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.