Overview

Location [1]
1p34.1
Protein [2]
DNA repair and recombination protein RAD54-like
Synonyms [1]
hHR54, RAD54A, HR54, hRAD54

RAD54L is altered in 0.56% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

RAD54L GENIE Cases - Top Diseases

The most common alterations in RAD54L are RAD54L Mutation (0.34%), RAD54L Amplification (0.04%), RAD54L Nonsense (0.02%), RAD54L Deletion (0.01%), and RAD54L Loss (0.01%) [3].

RAD54L GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of RAD54L in Diseases

Prostate Carcinoma +

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Bladder Urothelial Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Small Cell Lung Carcinoma +

Malignant Intestinal Neoplasm +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Penile Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.