Overview

Location [1]
1p34.1
Protein [2]
DNA repair and recombination protein RAD54-like
Synonyms [1]
hHR54, hRAD54, RAD54A, HR54

RAD54L is altered in 0.69% of all cancers with colorectal adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, uterine corpus neoplasm, and bladder carcinoma having the greatest prevalence of alterations [3].

RAD54L GENIE Cases - Top Diseases

The most common alterations in RAD54L are RAD54L Mutation (0.34%), RAD54L Amplification (0.04%), RAD54L Deletion (0.01%), RAD54L Loss (0.01%), and RAD54L C20_D21del (0.01%) [3].

RAD54L GENIE Cases - Top Alterations

Significance of RAD54L in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Fallopian Tube Carcinoma +

Gastric Carcinoma +

Penile Carcinoma +

Endometrial Carcinoma +

Uveal Melanoma +

Diffuse Large B-Cell Lymphoma +

Squamous Cell Lung Carcinoma +

Esophageal Adenocarcinoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Peritoneal Carcinoma +

Primary Peritoneal Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.