Location [1]
MAP kinase signaling
Protein [2]
RAF proto-oncogene serine/threonine-protein kinase
Synonyms [1]
c-Raf, NS5, CRAF, CMD1NN, Raf-1

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, rearrangements, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

RAF1 is altered in 1.21% of all cancers with colon adenocarcinoma, lung adenocarcinoma, bladder urothelial carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

RAF1 GENIE Cases - Top Diseases

The most common alterations in RAF1 are RAF1 Mutation (0.90%), RAF1 Amplification (0.25%), RAF1 S257L (0.09%), RAF1 Fusion (0.08%), and RAF1 S259F (0.03%) [3].

RAF1 GENIE Cases - Top Alterations

Significance of RAF1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Glioma +

Low Grade Glioma +

Soft Tissue Sarcoma +

Breast Carcinoma +

Thyroid Gland Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Urothelial Carcinoma +

Cutaneous Melanoma +

Bladder Carcinoma +

Endometrial Carcinoma +

Malignant Uterine Neoplasm +

Nasopharyngeal Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Lip And Oral Cavity Carcinoma +

Embryonal Rhabdomyosarcoma +

Malignant Laryngeal Neoplasm +

Pilocytic Astrocytoma +

Ganglioglioma +

Malignant Peripheral Nerve Sheath Tumor +

Diffuse Glioma +

Lung Carcinoma +

Head And Neck Carcinoma +

Cervical Carcinoma +

Astrocytic Tumor +

Malignant Salivary Gland Neoplasm +

Esophageal Carcinoma +

Neuronal And Mixed Neuronal-Glial Tumors +

Hepatocellular Carcinoma +

Bile Duct Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Gastrointestinal Stromal Tumor +

Oropharyngeal Carcinoma +

Neuroblastoma +

Acute Myeloid Leukemia +

Bronchogenic Carcinoma +

Chronic Myelomonocytic Leukemia +

Dysembryoplastic Neuroepithelial Tumor +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gangliocytoma +

Low-Grade Neuroepithelial Tumor, NOS +

Multiple Myeloma +

Myelodysplastic Syndromes +

Nasal Cavity And Paranasal Sinus Carcinoma +

Neurofibromatosis Type 1 +

Pancreatic Ductal Adenocarcinoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.