Overview

Location [1]
3p25.2
Pathway
MAP kinase signaling
Synonyms [1]
Raf-1, NS5, c-Raf, CMD1NN, CRAF

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, rearrangements, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of RAF1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Glioma +

Soft Tissue Sarcoma +

Thyroid Gland Carcinoma +

Acute Myeloid Leukemia +

Astrocytic Tumor +

Bile Duct Carcinoma +

Bladder Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Chronic Myelomonocytic Leukemia +

Cutaneous Melanoma +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gangliocytoma +

Ganglioglioma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Hepatobiliary Neoplasm +

Hepatocellular Carcinoma +

Lip And Oral Cavity Carcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Lung Carcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Salivary Gland Neoplasm +

Malignant Uterine Neoplasm +

Multiple Myeloma +

Myelodysplastic Syndromes +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neuroblastoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Oropharyngeal Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.