Overview

Location [1]
3p25.2
Pathway
MAP kinase signaling
Protein [2]
RAF proto-oncogene serine/threonine-protein kinase
Synonyms [1]
Raf-1, CMD1NN, CRAF, c-Raf, NS5

Raf-1 proto-oncogene, serine/threonine kinase (RAF1, also known as CRAF) is a gene that encodes a protein that functions downstream of RAS and activates MEK1 and MEK2. Fusions, rearrangements, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

RAF1 is altered in 1.07% of all cancers with colon adenocarcinoma, bladder urothelial carcinoma, lung adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

RAF1 GENIE Cases - Top Diseases

The most common alterations in RAF1 are RAF1 Mutation (0.98%), RAF1 Amplification (0.25%), RAF1 S257L (0.10%), RAF1 R391W (0.03%), and RAF1 S259F (0.03%) [3].

RAF1 GENIE Cases - Top Alterations

Significance of RAF1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Glioma +

Breast Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Histiocytic And Dendritic Cell Neoplasm +

Neuroblastoma +

Cutaneous Melanoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Endometrial Carcinoma +

Malignant Uterine Neoplasm +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Lung Carcinoma +

Low Grade Glioma +

Soft Tissue Sarcoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Embryonal Rhabdomyosarcoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Peripheral Nerve Sheath Tumor +

Malignant Salivary Gland Neoplasm +

Multiple Myeloma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Neurofibromatosis Type 1 +

Oropharyngeal Carcinoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.