Overview

Location [1]
16p13.3
Protein [2]
Structure-specific endonuclease subunit SLX4
Synonyms [1]
FANCP, BTBD12, MUS312

SLX4 structure-specific endonuclease subunit (SLX4) is a gene that encodes a protein that is part of a complex required for specific types of DNA repair and for cellular responses to replication fork failure. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as colon cancer, skin cancer, and stomach cancer.

SLX4 is altered in 2.55% of all cancers with colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, and melanoma having the greatest prevalence of alterations [3].

SLX4 GENIE Cases - Top Diseases

The most common alterations in SLX4 are SLX4 Mutation (1.23%), SLX4 Loss (0.04%), SLX4 Amplification (0.02%), SLX4 P469Hfs*4 (0.02%), and SLX4 R1034H (0.01%) [3].

SLX4 GENIE Cases - Top Alterations

Significance of SLX4 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Non-Hodgkin Lymphoma +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Gastric Carcinoma +

Colorectal Carcinoma +

Squamous Cell Lung Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Soft Tissue Sarcoma +

Cholangiocarcinoma +

Pancreatic Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Osteosarcoma +

Diffuse Large B-Cell Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Melanoma +

Bladder Urothelial Carcinoma +

Gastric Adenocarcinoma +

Malignant Gastric Neoplasm +

Malignant Intestinal Neoplasm +

Colorectal Adenocarcinoma +

Biliary Tract Carcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Bile Duct Adenocarcinoma +

Kidney Carcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Ewing Sarcoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Leiomyosarcoma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Mesothelioma +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Multiple Myeloma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Rhabdomyosarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.