Overview

Location [1]
16p13.3
Protein [2]
Structure-specific endonuclease subunit SLX4
Synonyms [1]
MUS312, BTBD12, FANCP

SLX4 structure-specific endonuclease subunit (SLX4) is a gene that encodes a protein that is part of a complex required for specific types of DNA repair and for cellular responses to replication fork failure. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as colon cancer, skin cancer, and stomach cancer.

SLX4 is altered in 3.39% of all cancers with colorectal adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, melanoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

SLX4 GENIE Cases - Top Diseases

The most common alterations in SLX4 are SLX4 Mutation (1.23%), SLX4 Mutation (germline) (1.23%), SLX4 Loss (0.04%), SLX4 Amplification (0.02%), and SLX4 P469Hfs*4 (0.02%) [3].

SLX4 GENIE Cases - Top Alterations

Significance of SLX4 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Colorectal Carcinoma +

Fallopian Tube Carcinoma +

Gastric Carcinoma +

Cholangiocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Primary Peritoneal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Endometrial Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Anal Carcinoma +

Urothelial Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Osteosarcoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Mesothelioma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Leiomyosarcoma +

Pancreatic Carcinoma +

Clear Cell Renal Cell Carcinoma +

Mantle Cell Lymphoma +

Multiple Myeloma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.