Location [1]
Protein [2]
Structure-specific endonuclease subunit SLX4
Synonyms [1]

SLX4 structure-specific endonuclease subunit (SLX4) is a gene that encodes a protein that is part of a complex required for specific types of DNA repair and for cellular responses to replication fork failure. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as colon cancer, skin cancer, and stomach cancer.

SLX4 is altered in 3.16% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

SLX4 GENIE Cases - Top Diseases

The most common alterations in SLX4 are SLX4 Mutation (2.79%), SLX4 Loss (0.13%), SLX4 Amplification (0.10%), SLX4 R1021C (0.02%), and SLX4 E179D (0.08%) [3].

SLX4 GENIE Cases - Top Alterations

Significance of SLX4 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Gastric Carcinoma +

Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Soft Tissue Sarcoma +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Head And Neck Carcinoma +

Esophageal Carcinoma +

Osteosarcoma +

High Grade Ovarian Serous Adenocarcinoma +

Pancreatic Carcinoma +

Gastrointestinal Stromal Tumor +

Medulloblastoma +

Diffuse Large B-Cell Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Melanoma +

Malignant Small Intestinal Neoplasm +

Bladder Urothelial Carcinoma +

Anal Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

Ampulla Of Vater Carcinoma +

Gastric Adenocarcinoma +

Malignant Gastric Neoplasm +

Multiple Myeloma +

Ewing Sarcoma +

Malignant Central Nervous System Neoplasm +

Malignant Esophagogastric Neoplasm +

Glioma +

Biliary Tract Carcinoma +

Esophageal Adenocarcinoma +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Leiomyosarcoma +

Malignant Ovarian Epithelial Tumor +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Mesothelioma +

Clear Cell Renal Cell Carcinoma +

Rhabdomyosarcoma +

Mantle Cell Lymphoma +

Neuroblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.