Biomarkers /
STAG2
Overview
Stromal antigen 2 (STAG2) is a gene that codes for cohesin subunit SA-2,a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (PMID: 19886810). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (PMID: 24854081; PMID: 23443460). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014; PMID: 24854081).
Clinical Trials
Significance of STAG2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.