Location [1]
DNA damage/repair
Protein [2]
Cohesin subunit SA-2
Synonyms [1]
SA2, SA-2, SCC3B, HPE13, MKMS, NEDXCF, bA517O1.1

Stromal antigen 2 (STAG2) is a gene that codes for cohesin subunit SA-2,a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (PMID: 19886810). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (PMID: 24854081PMID: 23443460). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014PMID: 24854081).

STAG2 is altered in 2.66% of all cancers with lung adenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

STAG2 GENIE Cases - Top Diseases

The most common alterations in STAG2 are STAG2 Mutation (1.99%), STAG2 Nonsense (0.47%), STAG2 Loss (0.15%), STAG2 Amplification (0.06%), and STAG2 Q340K (2.16%) [3].

STAG2 GENIE Cases - Top Alterations

Significance of STAG2 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Myelodysplastic Syndromes +

Primary Peritoneal Carcinoma +

Acute Myeloid Leukemia +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Endometrial Carcinoma +

Fallopian Tube Carcinoma +

Secondary Acute Myeloid Leukemia +

Head And Neck Squamous Cell Carcinoma +

Non-Hodgkin Lymphoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Myelodysplastic Syndrome With Excess Blasts-2 +

Penile Carcinoma +

Bladder Urothelial Carcinoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Small Cell Lung Carcinoma +

Glioblastoma +

Melanoma +

Therapy-Related Acute Myeloid Leukemia +

Myelodysplastic/Myeloproliferative Neoplasm +

Myeloid Neoplasm +

Chronic Myelomonocytic Leukemia +

Malignant Small Intestinal Neoplasm +

Anal Carcinoma +

Malignant Intestinal Neoplasm +

Therapy-Related Myelodysplastic Syndrome +

Diffuse Large B-Cell Lymphoma +

Mantle Cell Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Lymphoma +

Head And Neck Carcinoma +

Malignant Ovarian Epithelial Tumor +

Cholangiocarcinoma +

Anaplastic Astrocytoma +

Pancreatic Adenocarcinoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Sarcoma +

Malignant Esophagogastric Neoplasm +

Esophageal Carcinoma +

Soft Tissue Sarcoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Gastrointestinal Stromal Tumor +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Ampulla Of Vater Carcinoma +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.