Overview

Location [1]
Xq25
Pathway
DNA damage/repair
Protein [2]
Cohesin subunit SA-2
Synonyms [1]
SA-2, SCC3B, SA2, bA517O1.1

Stromal antigen 2 (STAG2) is a gene that codes for cohesin subunit SA-2,a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (PMID: 19886810). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (PMID: 24854081PMID: 23443460). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014PMID: 24854081).

STAG2 is altered in 2.13% of all cancers with lung adenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, acute myeloid leukemia, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

STAG2 GENIE Cases - Top Diseases

The most common alterations in STAG2 are STAG2 Mutation (2.36%), STAG2 Nonsense (0.45%), STAG2 Frameshift (0.35%), STAG2 Loss (0.10%), and STAG2 Amplification (0.05%) [3].

STAG2 GENIE Cases - Top Alterations

Significance of STAG2 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Primary Peritoneal Carcinoma +

Acute Myeloid Leukemia +

Non-Small Cell Lung Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Fallopian Tube Carcinoma +

Urothelial Carcinoma +

Myelodysplastic Syndromes +

Endometrial Carcinoma +

Pancreatic Carcinoma +

Cholangiocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Bladder Urothelial Carcinoma +

Bladder Carcinoma +

Myeloid Neoplasm +

Glioblastoma +

Melanoma +

Small Cell Lung Carcinoma +

Malignant Intestinal Neoplasm +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Kidney Carcinoma +

Esophageal Carcinoma +

Lymphoma +

Malignant Esophagogastric Neoplasm +

Sarcoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Clear Cell Renal Cell Carcinoma +

Pancreatic Adenocarcinoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Anaplastic Astrocytoma +

Chronic Myelomonocytic Leukemia +

Diffuse Large B-Cell Lymphoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Penile Carcinoma +

Secondary Acute Myeloid Leukemia +

Soft Tissue Sarcoma +

Therapy-Related Acute Myeloid Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.