Overview

Significance of del(17)(p10) in Diseases

Acute Myeloid Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Chronic Lymphocytic Leukemia +

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Plasma Cell Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

Medulloblastoma +

Mantle Cell Lymphoma +

Secondary Acute Myeloid Leukemia +

Small Lymphocytic Lymphoma +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Diffuse Large B-Cell Lymphoma +

Medulloblastoma, Non-WNT/Non-SHH +

Smoldering Plasma Cell Myeloma +

Acute Biphenotypic Leukemia +

Acute Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Double-Hit Lymphoma +

Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myeloproliferative Neoplasm +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Waldenstrom Macroglobulinemia +

B-Cell Acute Lymphoblastic Leukemia +

B-Cell Prolymphocytic Leukemia +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Desmoplastic/Nodular Medulloblastoma +

Follicular Lymphoma +

Large Cell/Anaplastic Medulloblastoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Myelofibrosis +

Peripheral T-Cell Lymphoma +

Prolymphocytic Leukemia +

Richter Syndrome +

Therapy-Related Myelodysplastic Syndrome +

Acute Bilineal Leukemia +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia With Myelodysplasia-Related Changes +

Adult Acute Lymphoblastic Leukemia +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Aplastic Anemia +

Atypical Teratoid/Rhabdoid Tumor +

Burkitt Lymphoma +

Diffuse Glioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

Glioblastoma +

High-Grade Glioma, NOS +

Histiocytic And Dendritic Cell Neoplasm +

Indolent Non-Hodgkin Lymphoma +

Intracranial Primitive Neuroectodermal Neoplasm +

Juvenile Myelomonocytic Leukemia +

Leukemia +

Lip And Oral Cavity Carcinoma +

Lymphoblastic Lymphoma +

Malignant Glioma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Mature T-Cell And NK-Cell Neoplasm +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +

Myeloma +

Oral Cavity Carcinoma +

Oral Intraepithelial Neoplasia +

Oral Neoplasm +

Pineoblastoma +

Plasma Cell Neoplasm +

Plasmacytoma +

Polycythemia Vera +

Primary Myelofibrosis +

Refractory Anemia +

Refractory Anemia With Excess Blasts +

Secondary Myelodysplastic Syndrome +

Small Lymphocytic Leukemia +

T-Cell Non-Hodgkin Lymphoma +

Therapy-Related Chronic Myelomonocytic Leukemia +

Triple-Hit Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.