Biomarker-Directed Therapies

Significance of ER Positive in Diseases

Breast Carcinoma +

Malignant Solid Tumor +

Breast Adenocarcinoma +

Ovarian Carcinoma +

Ductal Carcinoma In Situ +

Endometrial Carcinoma +

Breast Invasive Ductal Carcinoma +

Fallopian Tube Carcinoma +

Non-Small Cell Lung Carcinoma +

Primary Peritoneal Carcinoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Pancreatic Adenocarcinoma +

Renal Cell Carcinoma +

Breast Lobular Carcinoma In Situ +

Cancer +

Cervical Carcinoma +

Desmoid-Type Fibromatosis +

Diffuse Gastric Adenocarcinoma +

Diffuse Large B-Cell Lymphoma +

Endometrial Adenocarcinoma +

Endometrial Clear Cell Adenocarcinoma +

Endometrial Dedifferentiated Carcinoma +

Endometrial Endometrioid Adenocarcinoma +

Endometrial Mixed Adenocarcinoma +

Endometrial Mucinous Adenocarcinoma +

Endometrial Serous Adenocarcinoma +

Endometrial Squamous Cell Carcinoma +

Endometrial Transitional Cell Carcinoma +

Endometrial Undifferentiated Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Neuroendocrine Tumors +

Germ Cell Tumor +

Hypopharyngeal Squamous Cell Carcinoma +

Inflammatory Breast Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Lobular Breast Carcinoma +

Lung Neuroendocrine Neoplasm +

Lymphoma +

Melanoma +

Multiple Myeloma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Pancreatic Neuroendocrine Carcinoma +

Pancreatic Neuroendocrine Neoplasm +

Pancreatic Neuroendocrine Tumor +

Peripheral T-Cell Lymphoma +

Peritoneal Carcinoma +

Peritoneal Mesothelioma +

Prostate Adenocarcinoma +

Sarcoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

Uterine Sarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.