Overview

Variant Type
Low Expression

Biomarker-Directed Therapies

Significance of PD-L1 Low Expression in Diseases

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Urothelial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

Malignant Solid Tumor +

Melanoma +

Head And Neck Squamous Cell Carcinoma +

Colorectal Carcinoma +

Renal Cell Carcinoma +

Bladder Carcinoma +

Bladder Urothelial Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastric Carcinoma +

Ovarian Carcinoma +

Urethral Urothelial Carcinoma +

Ampulla Of Vater Clear Cell Adenocarcinoma +

Bladder Clear Cell Adenocarcinoma +

Carcinoma Of Unknown Primary Origin +

Carcinosarcoma +

Cervical Carcinoma +

Cervical Clear Cell Adenocarcinoma +

Clear Cell Adenocarcinoma +

Clear Cell Hepatocellular Carcinoma +

Clear Cell Odontogenic Carcinoma +

Clear Cell Sarcoma Of Soft Tissue +

Clear Cell Sarcoma Of The Kidney +

Clear Cell Squamous Cell Skin Carcinoma +

Endometrial Carcinoma +

Endometrial Clear Cell Adenocarcinoma +

Esophageal Carcinoma +

Extrahepatic Bile Duct Clear Cell Adenocarcinoma +

Fallopian Tube Clear Cell Adenocarcinoma +

Head And Neck Carcinoma +

Hepatocellular Carcinoma +

Hereditary Clear Cell Renal Cell Carcinoma +

Hodgkin Lymphoma +

Infiltrating Renal Pelvis And Ureter Urothelial Carcinoma +

Large Cell Lung Carcinoma, Clear Cell Variant +

Liver And Intrahepatic Bile Duct Carcinoma +

Lymphoma +

Malignant Mesothelioma +

Malignant Ovarian Clear Cell Tumor +

Merkel Cell Carcinoma +

Mesothelioma +

Mucosal Melanoma +

Non-Hodgkin Lymphoma +

Ovarian Clear Cell Tumor +

Pancreatic Ductal Adenocarcinoma +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Renal Pelvis Urothelial Carcinoma +

Renal Pelvis And Ureter Urothelial Carcinoma +

Skin Clear Cell Basal Cell Carcinoma +

Skin Squamous Cell Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Thymic Clear Cell Carcinoma +

Ureter Urothelial Carcinoma +

Urethral Clear Cell Adenocarcinoma +

Uterine Ligament Clear Cell Adenocarcinoma +

Vulvar Clear Cell Hidradenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.