Associated Diseases


Biomarker-Directed Therapies

Significance of TMB-High in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Bladder Carcinoma +

Melanoma +

Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Breast Carcinoma +

Endometrial Carcinoma +

Cervical Carcinoma +

Glioma +

Central Nervous System Neoplasm +

Cervical Squamous Cell Carcinoma +

Ependymoma +

Head And Neck Carcinoma +

Malignant Glioma +

Medulloblastoma +

Pancreatic Carcinoma +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Vulvar Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Alveolar Rhabdomyosarcoma +

Anal Canal Squamous Cell Carcinoma +

Anal Squamous Cell Carcinoma +

Appendix Neuroendocrine Tumor +

Atypical Teratoid/Rhabdoid Tumor +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Biliary Tract Carcinoma +

Bronchogenic Carcinoma +

Cancer +

Carcinosarcoma +

Childhood Central Nervous System Embryonal Carcinoma +

Cholangiocarcinoma +

Colorectal Neuroendocrine Tumor +

Constitutional Mismatch Repair Deficiency Syndrome +

Desmoplastic Small Round Cell Tumor +

Diffuse Intrinsic Pontine Glioma +

Embryonal Rhabdomyosarcoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Endometrial Adenocarcinoma +

Endometrial Serous Adenocarcinoma +

Endometrial Undifferentiated Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Of Bone +

Gallbladder Adenocarcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Glioblastoma +

Head And Neck Squamous Cell Carcinoma +

High-Grade Endometrial Stromal Sarcoma +

Invasive Breast Carcinoma +

Leiomyosarcoma +

Lung Carcinoma +

Lung Neuroendocrine Neoplasm +

Lymphoma +

Lynch Syndrome +

Malignant Brain Neoplasm +

Malignant Salivary Gland Neoplasm +

Malignant Uterine Neoplasm +

Mesothelioma +

Multiple Myeloma +

Neuroblastoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Ovarian Clear Cell Tumor +

Pancreatic Neuroendocrine Tumor +

Prostate Small Cell Carcinoma +

Rhabdoid Tumor +

Salivary Gland Carcinoma +

Skin Squamous Cell Carcinoma +

Small Intestinal Neuroendocrine Tumor +

Squamous Cell Lung Carcinoma +

Synovial Sarcoma +

Thyroid Gland Carcinoma +

Undifferentiated (Embryonal) Sarcoma +

Uterine Corpus Carcinosarcoma +

Vaginal Squamous Cell Carcinoma +

Wilms Tumor +

Xeroderma Pigmentosum +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.