Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the bladder epithelium. Approximately 90% of the bladder carcinomas are transitional cell carcinomas. The remainder are squamous cell carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas. [1]

Biomarker-Directed Therapies

Significant Genes in Bladder Carcinoma

ABL1 +

ABL2 +

ACVR1B +

AKT1 +

ALK +

APC +

ARID1A +

ASXL1 +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRD4 +

BRIP1 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CSF1R +

CYLD +

DICER1 +

DNMT3A +

DOT1L +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

EZH2 +

FANCA +

FANCC +

FANCE +

FANCG +

FANCL +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

GATA3 +

HGF +

IDH1 +

IKBKE +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2C +

KMT2D +

KRAS +

MAGI2 +

MAP3K1 +

MED12 +

MEN1 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NPM1 +

NRAS +

NRG1 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PTCH1 +

PTPN11 +

RAD51 +

RAD51C +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RUNX1 +

SETD2 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SMO +

SOX9 +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STK11 +

TACC3 +

TAF1 +

TBX3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

VHL +

XPO1 +

Disease Details

Synonyms
Cancer of Bladder, Carcinoma of the Urinary Bladder, Bladder carcinoma (NOS), Carcinoma of Bladder, Carcinoma of Urinary Bladder, Cancer of the Bladder, Urinary Bladder Cancer, Urinary Bladder Carcinoma, Cancer of Urinary Bladder, Bladder Cancer, Cancer of the Urinary Bladder, Carcinoma of the Bladder
Parent(s)
Malignant Bladder Neoplasm
Children
Bladder Adenocarcinoma, Non-Muscle Invasive Bladder Carcinoma, Bladder Squamous Cell Carcinoma, Bladder Urachal Carcinoma, Bladder Small Cell Neuroendocrine Carcinoma, and Bladder Urothelial Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.