Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the bladder epithelium. Approximately 90% of the bladder carcinomas are transitional cell carcinomas. The remainder are squamous cell carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas. [1]

Bladder carcinomas most frequently harbor alterations in TP53, KDM6A, KMT2D, FGFR3, and ARID1A [2].

Most Commonly Altered Genes in Bladder Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, FGFR3 Mutation, and KMT2D Mutation are the most common alterations in bladder carcinoma [2].

Top Alterations in Bladder Carcinoma

Biomarker-Directed Therapies

Significant Genes in Bladder Carcinoma

ABL1 +

ABL2 +

ACVR1B +

AKT1 +

ALK +

APC +

ARID1A +

ASXL1 +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BLM +

BRAF +

BRCA1 +

BRCA2 +

BRD4 +

BRIP1 +

CCND1 +

CDK12 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CHEK1 +

CHEK2 +

CSF1R +

CYLD +

DICER1 +

DNMT3A +

DOT1L +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

EZH2 +

FANCC +

FANCE +

FANCG +

FANCL +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

GATA3 +

HGF +

IDH1 +

IKBKE +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2C +

KMT2D +

KRAS +

MAGI2 +

MAP3K1 +

MED12 +

MEN1 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NPM1 +

NRAS +

NRG1 +

NSD1 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PMS1 +

PMS2 +

POLD1 +

POLE +

PTCH1 +

PTPN11 +

RAD51 +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

RUNX1 +

SETD2 +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SMO +

SOX9 +

SS18 +

SSBP1 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

STAG2 +

STK11 +

TACC3 +

TAF1 +

TBX3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

VHL +

XPO1 +

Disease Details

Synonyms
Cancer of the Bladder, Cancer of Bladder, Bladder Cancer, Bladder carcinoma (NOS), Urinary Bladder Carcinoma, Urinary Bladder Cancer, Carcinoma of the Urinary Bladder, Cancer of Urinary Bladder, Cancer of the Urinary Bladder, Carcinoma of Urinary Bladder, Carcinoma of Bladder, Carcinoma of the Bladder
Parent(s)
Malignant Bladder Neoplasm
Children
Non-Muscle Invasive Bladder Carcinoma, Bladder Adenocarcinoma, Bladder Urachal Carcinoma, Bladder Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, and Bladder Small Cell Neuroendocrine Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.