Diseases /
Bladder Urothelial Carcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival. [1]
Bladder urothelial carcinomas most frequently harbor alterations in TP53, KDM6A, KMT2D, FGFR3, and ARID1A [2].
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, FGFR3 Mutation, and KMT2D Mutation are the most common alterations in bladder urothelial carcinoma [2].
Clinical Trials
Significant Genes in Bladder Urothelial Carcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.