Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BIRC2 +

BIRC3 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CARD11 +

CCND1 +

CCNE1 +

CD79A +

CD79B +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NFKBIA +

NPM1 +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TNFAIP3 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Cancer of the Uterine Cervix, Cervix Cancer, Cervical cancer, NOS, Carcinoma of the Cervix Uteri, Carcinoma of Cervix Uteri, Cervix Uteri Carcinoma, Cancer of the Cervix, Cancer of Uterine Cervix, Carcinoma of Cervix, Uterine Cervix Cancer, Carcinoma of Uterine Cervix, Uterine Cervix Carcinoma, Cancer of Cervix, Cervix Carcinoma, Carcinoma of the Cervix, Carcinoma of the Uterine Cervix, Cervical Cancer
Parent(s)
Malignant Cervical Neoplasm
Children
Cervical Undifferentiated Carcinoma, Exocervical Carcinoma, Cervical Neuroendocrine Carcinoma, Cervical Adenoid Basal Carcinoma, Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Endocervical Carcinoma, Cervical Adenoid Cystic Carcinoma, Cervical Adenosquamous Carcinoma, and Infiltrating Cervical Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.