Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and PTEN [2].

Most Commonly Altered Genes in Cervical Carcinoma

PIK3CA Mutation, TP53 Mutation, PIK3CA E545K, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in cervical carcinoma [2].

Top Alterations in Cervical Carcinoma

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NPM1 +

NRG1 +

NTRK1 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Carcinoma of Cervix Uteri, Carcinoma of the Cervix Uteri, Uterine Cervix Carcinoma, Cervix Carcinoma, Carcinoma of Cervix, Uterine Cervix Cancer, Cancer of Cervix, Cancer of Uterine Cervix, Carcinoma of the Cervix, Cervical Cancer, Cervix Uteri Carcinoma, Carcinoma of the Uterine Cervix, Cervix Cancer, Cervical cancer, NOS, Cancer of the Cervix, Cancer of the Uterine Cervix, Carcinoma of Uterine Cervix
Parent(s)
Malignant Cervical Neoplasm
Children
Cervical Adenoid Cystic Carcinoma, Endocervical Carcinoma, Cervical Squamous Cell Carcinoma, Infiltrating Cervical Carcinoma, Cervical Undifferentiated Carcinoma, Exocervical Carcinoma, Cervical Neuroendocrine Carcinoma, Cervical Adenocarcinoma, Cervical Adenoid Basal Carcinoma, and Cervical Adenosquamous Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.