Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KMT2D, KRAS, and ERBB2 [2].

Most Commonly Altered Genes in Cervical Carcinoma

PIK3CA Mutation (somatic), PIK3CA Mutation, PIK3CA E545K, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in cervical carcinoma [2].

Top Alterations in Cervical Carcinoma

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

ATM +

ATR +

ATRX +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CDK12 +

CDKN2A +

CHEK1 +

CHEK2 +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HDAC1 +

HDAC2 +

MDM2 +

MDM4 +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MUTYH +

MYC +

NBN +

NPM1 +

PALB2 +

PARP1 +

PARP2 +

PMS1 +

PMS2 +

PPP2R1A +

PPP2R2A +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RB1 +

SLX4 +

STAG2 +

STK11 +

TP53 +

XRCC1 +

Disease Details

Synonyms
Cervical cancer, NOS, Cervix Cancer, Cancer of the Cervix, Cervix Carcinoma, Carcinoma of Cervix, Uterine Cervix Carcinoma, Cancer of the Uterine Cervix, Cervical Cancer, Cervix Uteri Carcinoma, Carcinoma of Cervix Uteri, Carcinoma of the Cervix Uteri, Uterine Cervix Cancer, Cancer of Uterine Cervix, Carcinoma of the Uterine Cervix, Cancer of Cervix, Carcinoma of the Cervix, Carcinoma of Uterine Cervix
Parent(s)
Malignant Cervical Neoplasm
Children
Cervical Adenoid Basal Carcinoma, Cervical Neuroendocrine Carcinoma, Cervical Undifferentiated Carcinoma, Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Endocervical Carcinoma, Exocervical Carcinoma, Cervical Adenoid Cystic Carcinoma, and Infiltrating Cervical Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.