Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and PTEN [2].

Most Commonly Altered Genes in Cervical Carcinoma

PIK3CA Mutation, TP53 Mutation, PIK3CA E545K, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in cervical carcinoma [2].

Top Alterations in Cervical Carcinoma

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NPM1 +

NRG1 +

NTRK1 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Cancer of the Uterine Cervix, Carcinoma of Cervix Uteri, Carcinoma of Cervix, Carcinoma of Uterine Cervix, Cervix Uteri Carcinoma, Uterine Cervix Cancer, Cervical Cancer, Carcinoma of the Cervix, Cervix Cancer, Cervical cancer, NOS, Cancer of Uterine Cervix, Carcinoma of the Uterine Cervix, Uterine Cervix Carcinoma, Cancer of Cervix, Cancer of the Cervix, Cervix Carcinoma, Carcinoma of the Cervix Uteri
Parent(s)
Malignant Cervical Neoplasm
Children
Cervical Undifferentiated Carcinoma, Cervical Neuroendocrine Carcinoma, Cervical Adenosquamous Carcinoma, Cervical Adenoid Cystic Carcinoma, Infiltrating Cervical Carcinoma, Cervical Squamous Cell Carcinoma, Endocervical Carcinoma, Exocervical Carcinoma, Cervical Adenoid Basal Carcinoma, and Cervical Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.