Diseases /
Cervical Carcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]
Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and ERBB2 [2].
PIK3CA Mutation, PIK3CA Codon 545 Missense, PIK3CA E545K, TP53 Mutation, and TP53 Missense are the most common alterations in cervical carcinoma [2].
Biomarker-Directed Therapies
Clinical Trials
Significant Genes in Cervical Carcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.