Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and ERBB2 [2].

Most Commonly Altered Genes in Cervical Carcinoma

PIK3CA Mutation, PIK3CA Codon 545 Missense, PIK3CA E545K, TP53 Mutation, and TP53 Missense are the most common alterations in cervical carcinoma [2].

Top Alterations in Cervical Carcinoma

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCND1 +

CCNE1 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NPM1 +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Carcinoma of Uterine Cervix, Cervical Cancer, Cancer of Uterine Cervix, Carcinoma of Cervix, Carcinoma of Cervix Uteri, Cancer of the Cervix, Cervix Cancer, Carcinoma of the Uterine Cervix, Cancer of the Uterine Cervix, Cancer of Cervix, Cervix Uteri Carcinoma, Cervical cancer, NOS, Uterine Cervix Carcinoma, Cervix Carcinoma, Uterine Cervix Cancer, Carcinoma of the Cervix, Carcinoma of the Cervix Uteri
Parent(s)
Malignant Cervical Neoplasm
Children
Exocervical Carcinoma, Cervical Neuroendocrine Carcinoma, Infiltrating Cervical Carcinoma, Cervical Adenoid Cystic Carcinoma, Cervical Adenosquamous Carcinoma, Endocervical Carcinoma, Cervical Adenocarcinoma, Cervical Adenoid Basal Carcinoma, Cervical Squamous Cell Carcinoma, and Cervical Undifferentiated Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.