Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. [1]

Cervical carcinomas most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and ERBB2 [2].

Most Commonly Altered Genes in Cervical Carcinoma

PIK3CA Mutation, PIK3CA Codon 545 Missense, PIK3CA E545K, TP53 Mutation, and TP53 Missense are the most common alterations in cervical carcinoma [2].

Top Alterations in Cervical Carcinoma

Biomarker-Directed Therapies

Significant Genes in Cervical Carcinoma

AKT1 +

ALK +

ARID1A +

ATM +

ATR +

ATRX +

BARD1 +

BIRC2 +

BIRC3 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CARD11 +

CCND1 +

CCNE1 +

CD79A +

CD79B +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CHEK1 +

CHEK2 +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

EXO1 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

HDAC1 +

HDAC2 +

KDR +

KIT +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

MUTYH +

MYC +

NBN +

NFKBIA +

NPM1 +

NRG1 +

NTRK1 +

NTRK2 +

NTRK3 +

PALB2 +

PARP1 +

PARP2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RB1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SLX4 +

SMARCB1 +

SSBP1 +

STAG2 +

STK11 +

TNFAIP3 +

TP53 +

TSC1 +

TSC2 +

VHL +

XRCC1 +

Disease Details

Synonyms
Cervical Cancer, Cervix Carcinoma, Cancer of Uterine Cervix, Carcinoma of the Cervix Uteri, Cancer of the Cervix, Cancer of Cervix, Cervical cancer, NOS, Cervix Uteri Carcinoma, Cancer of the Uterine Cervix, Uterine Cervix Carcinoma, Carcinoma of Cervix, Carcinoma of Cervix Uteri, Carcinoma of Uterine Cervix, Carcinoma of the Uterine Cervix, Cervix Cancer, Carcinoma of the Cervix, Uterine Cervix Cancer
Parent(s)
Malignant Cervical Neoplasm
Children
Cervical Squamous Cell Carcinoma, Endocervical Carcinoma, Cervical Undifferentiated Carcinoma, Cervical Adenoid Cystic Carcinoma, Cervical Adenoid Basal Carcinoma, Cervical Neuroendocrine Carcinoma, Cervical Adenocarcinoma, Exocervical Carcinoma, Infiltrating Cervical Carcinoma, and Cervical Adenosquamous Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.