Associated Genetic Biomarkers

Overview

NCI Definition: A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell lymphoma. [1]

Diffuse large B-cell lymphomas most frequently harbor alterations in KMT2D, CREBBP, TP53, BCL2, and PIM1 [2].

Most Commonly Altered Genes in Diffuse Large B-Cell Lymphoma

KMT2D Mutation, CREBBP Mutation, TP53 Mutation, MYD88 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in diffuse large B-cell lymphoma [2].

Top Alterations in Diffuse Large B-Cell Lymphoma

Significant Genes in Diffuse Large B-Cell Lymphoma

ABL1 +

AFF1 +

ALK +

ASXL1 +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BCL2 +

BCL6 +

BCR +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CBFB +

CCND1 +

CDK12 +

CHEK1 +

CHEK2 +

CREBBP +

DEK +

ELL +

EP300 +

ERBB2 +

ERCC2 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FLT3 +

HDAC1 +

HDAC2 +

HRAS +

IGH +

IRF4 +

JAK2 +

KIT +

KMT2A +

KRAS +

MAF +

MAFB +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLH1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

MSH2 +

MSH6 +

MTAP +

MUTYH +

MYC +

MYD88 +

MYH11 +

NBN +

NPM1 +

NRAS +

NUP214 +

PALB2 +

PARP1 +

PARP2 +

PBX1 +

PMS2 +

POLD1 +

POLE +

POLQ +

PPP2R1A +

PPP2R2A +

PRKDC +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RPN1 +

RUNX1 +

RUNX1T1 +

SLX4 +

STAG2 +

STK11 +

TCF3 +

TP53 +

WHSC1 +

XRCC1 +

Disease Details

Synonyms
Diffuse Large B Cell Lymphoma, DLBCL, Diffuse Large B-Cell Lymphoma (DLBCL)
Parent(s)
Mature B-Cell Non-Hodgkin Lymphoma
Children
Plasmablastic Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation, EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, ALK-Positive Large B-Cell Lymphoma, Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System, Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Mediastinal Large B-Cell Lymphoma, High Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements, Intravascular Large B-Cell Lymphoma, HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Effusion Lymphoma, and High Grade B-Cell Lymphoma, Not Otherwise Specified
OncoTree Name
Diffuse Large B-Cell Lymphoma
OncoTree Code
DLBCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.