Associated Genetic Biomarkers

Overview

NCI Definition: A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation. [1]

Biomarker-Directed Therapies

Significant Genes in Endometrial Carcinoma

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

ARID1A +

ATM +

ATR +

ATRX +

BAP1 +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CCNE1 +

CCNE2 +

CDK12 +

CHEK1 +

CHEK2 +

CRKL +

EGFR +

ERBB2 +

ERBB3 +

ERCC2 +

ERCC3 +

ERCC4 +

ERCC5 +

ERCC6 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

HDAC1 +

HDAC2 +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCL1 +

MCPH1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MUTYH +

MYC +

NBN +

NF1 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RET +

RICTOR +

ROS1 +

RPTOR +

SLX4 +

SMARCB1 +

SRC +

STAG2 +

STK11 +

TP53 +

TSC1 +

TSC2 +

XRCC1 +

Disease Details

Synonyms
Carcinoma of the Endometrium, CARCINOMA, ENDOMETRIAL, MALIGNANT, endometrial cancer, Carcinoma of Endometrium
Parent(s)
Malignant Endometrial Neoplasm
Children
Endometrial Transitional Cell Carcinoma, Endometrial Adenocarcinoma, Uterine Corpus Mesonephric Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Neuroendocrine Carcinoma, Endometrial Squamous Cell Carcinoma, Endometrial Adenosquamous Carcinoma, and Poorly Differentiated Endometrial Carcinoma
OncoTree Name
Endometrial Carcinoma
OncoTree Code
UCEC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.