Associated Genetic Biomarkers

Overview

NCI Definition: A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation. [1]

Endometrial carcinomas most frequently harbor alterations in PTEN, PIK3CA, TP53, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Endometrial Carcinoma

PTEN Mutation (somatic), PTEN Mutation (germline), PTEN Mutation, PIK3CA Mutation (somatic), and PIK3CA Mutation are the most common alterations in endometrial carcinoma [2].

Top Alterations in Endometrial Carcinoma

Significant Genes in Endometrial Carcinoma

AKT1 +

AKT2 +

AKT3 +

ARAF +

ATM +

ATR +

ATRX +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

C11ORF30 +

CDK12 +

CHEK1 +

CHEK2 +

CRKL +

EGFR +

ERBB2 +

ERBB3 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

HDAC1 +

HDAC2 +

HRAS +

IRS2 +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MDM2 +

MDM4 +

MET +

MLF1 +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MUTYH +

NBN +

NF1 +

NPM1 +

NRAS +

PALB2 +

PARP1 +

PARP2 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

POLE +

PPP2R1A +

PPP2R2A +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RET +

RICTOR +

RNF43 +

RPTOR +

SLX4 +

SRC +

STAG2 +

STK11 +

TSC1 +

TSC2 +

XRCC1 +

Disease Details

Synonyms
endometrial cancer, Carcinoma of Endometrium, CARCINOMA, ENDOMETRIAL, MALIGNANT, Carcinoma of the Endometrium
Parent(s)
Uterine Corpus Cancer
Children
Poorly Differentiated Endometrial Carcinoma, Uterine Corpus Neuroendocrine Neoplasm, Endometrial Dedifferentiated Carcinoma, Endometrial Small Cell Carcinoma, Endometrial Squamous Cell Carcinoma, Endometrial Undifferentiated Carcinoma, Endometrial Adenosquamous Carcinoma, Uterine Corpus Mesonephric Adenocarcinoma, Endometrial Adenocarcinoma, and Endometrial Transitional Cell Carcinoma
OncoTree Name
Endometrial Carcinoma
OncoTree Code
UCEC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.