Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [1]

Significant Genes in Glioma

ARAF +

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

CRKL +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FGFR1 +

FGFR2 +

FGFR3 +

H3F3A +

HGF +

HRAS +

IDH1 +

IDH2 +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MET +

MRE11A +

MYCN +

NBN +

NF1 +

NRAS +

PALB2 +

PDGFRA +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

SLX4 +

SRC +

TACC1 +

TACC3 +

Disease Details

Synonyms
Tumor of Neuroglia, Glial Neoplasm, Neuroglial Neoplasms, NEUROGLIAL TUMOR, UNDETERMINED, Tumors of Neuroglia, PEDIATRIC Brain glioma (NOS), Neoplasm of Neuroglia, Neoplasm of the Neuroglia, Neoplasms of Neuroglia, Neuroglial Tumor, Recurrent high-grade glioma, Tumor of the Neuroglia, Neuroglial Neoplasm, Glial Tumor, Brain glioma (NOS)
Parent(s)
Neuroepithelial Neoplasm
Children
Spinal Cord Glioma, Astrocytic Tumor, Ependymal Tumor, Oligodendroglial Tumor, Diffuse Glioma, Optic Nerve Glioma, Astroblastoma, Low Grade Glioma, Encapsulated Glioma, Malignant Glioma, Brain Stem Glioma, and Chordoid Glioma of the Third Ventricle

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.