Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [1]

Gliomas most frequently harbor alterations in IDH1, TP53, ATRX, KMT2D, and BRAF [2].

Most Commonly Altered Genes in Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in glioma [2].

Top Alterations in Glioma

Significant Genes in Glioma

ARAF +

BRAF +

CDKN2A +

CDKN2B +

CDKN2C +

CRKL +

EGFR +

ERBB2 +

FGF1 +

FGF3 +

FGFR1 +

FGFR2 +

FGFR3 +

H3F3A +

HGF +

HRAS +

IDH1 +

IDH2 +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MET +

MGMT +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MYCN +

NF1 +

NRAS +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

PMS1 +

PMS2 +

RAF1 +

SRC +

TACC1 +

TACC3 +

Disease Details

Synonyms
Neoplasm of the Neuroglia, Glial Tumor, Tumor of the Neuroglia, Neuroglial Neoplasms, Neuroglial Tumor, Tumor of Neuroglia, Tumors of Neuroglia, Neuroglial Neoplasm, Neoplasms of Neuroglia, Glial Neoplasm, Neoplasm of Neuroglia, NEUROGLIAL TUMOR, UNDETERMINED
Parent(s)
Neuroepithelial Neoplasm
Children
Ependymal Tumor, Encapsulated Glioma, Brain Stem Glioma, Low Grade Glioma, Astroblastoma, Astrocytic Tumor, Oligodendroglial Tumor, Chordoid Glioma of the Third Ventricle, Spinal Cord Glioma, Diffuse Glioma, and Malignant Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.