Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. [1]

Gliomas most frequently harbor alterations in TP53, IDH1, CDKN2A, PTEN, and EGFR [2].

Most Commonly Altered Genes in Glioma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in glioma [2].

Top Alterations in Glioma

Significant Genes in Glioma

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

FGFR1 +

FGFR2 +

FGFR3 +

H3F3A +

HGF +

HRAS +

IDH1 +

IDH2 +

KIAA1549 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MYCN +

NF1 +

NRAS +

PDGFRA +

PMS1 +

PMS2 +

RAF1 +

SRC +

TACC1 +

TACC3 +

Disease Details

Synonyms
Glial Tumor, Neoplasms of Neuroglia, NEUROGLIAL TUMOR, UNDETERMINED, Tumor of Neuroglia, Tumor of the Neuroglia, Neuroglial Tumor, Brain glioma (NOS), Neoplasm of the Neuroglia, Neoplasm of Neuroglia, Neuroglial Neoplasm, PEDIATRIC Brain glioma (NOS), Tumors of Neuroglia, Glial Neoplasm, Neuroglial Neoplasms
Parent(s)
Neuroepithelial Neoplasm
Children
Brain Stem Glioma, Astroblastoma, Diffuse Glioma, Ependymal Tumor, Spinal Cord Glioma, Malignant Glioma, Astrocytic Tumor, Low Grade Glioma, Chordoid Glioma of the Third Ventricle, Oligodendroglial Tumor, Optic Nerve Glioma, and Encapsulated Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.